LEGACY: Lung Cancer Screening in Individuals With a Lung Cancer Family History-Protocol B

Study summary

This research is being done to determine if an image-based deep learning model (Sybil) can accurately predict the likelihood of future lung cancer based on chest computed tomography (CT) imaging from individuals with a family history of lung cancer.

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Key things to know

Main goalNot specified

This describes the study’s primary purpose.

What is being studiedCT scan and Sybil

The study team can explain what participation involves.

Who it may be forFamily History of Lung Cancer

These are broad labels—not an eligibility decision.

Checked against the public recordLast updated Aug 25, 2026 · Source: ClinicalTrials.gov

Is enrollment open?Recruiting

The study is currently accepting participants.

What kind of study?Not applicable

Observational

Where is it offered?1 U.S. location

Locations may change over time.

Who runs it?Massachusetts General Hospital

Study sponsor

Study overview

What this study is about

Purpose: Not specified
Study type: Observational
Phase: Not applicable
Sponsor: Massachusetts General Hospital
Interventions being studied: Diagnostic Test: CT scan; Other: Sybil

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How this study is categorized

These labels come from structured fields and exact terms in the public record.

Public criteria

Who may be able to participate

The sponsor separates these requirements into two groups. You do not need to interpret them alone—use them to guide a conversation with the study team.

Requirements people may need to meetInclusion criteria

≥18 years of age
Positive family history of lung cancer (defined as):
Has ≥1 first-degree relative OR
Has ≥2 second-degree relatives with a diagnosis of non-small cell lung cancer or small cell lung cancer (NB: a first-degree relative = parent, sibling, or child, a second-degree relative = grandparent, blood-related aunt or uncle, grandchild, blood-related niece or nephew, half-sibling)
Willing to provide images from at least one previously obtained CT Chest scan, if available.

Reasons someone may not be able to joinExclusion criteria

\- None

Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.

Study sites

U.S. locations

Massachusetts General HospitalBoston, Massachusetts

Source and freshness
Processed from ClinicalTrials.gov. Last public update: Aug 25, 2026. Always confirm current availability with the study team.

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