Using Xe MRI to Guide Radiation Therapy for Lung Cancer
The purpose of this research study is to explore using MRI scans with xenon to better image lung function, how lung function changes after radiation therapy, and to guide radiation therapy away from parts of the lung that have good function. This project is foundational to performing additional studies to establish if novel MRI imaging can serve as a guidance tool for lung cancer radiation treatment.
Ask AI to explain this studyKey things to know
This describes the study’s primary purpose.
Plus 4 other study approaches.
These are broad labels—not an eligibility decision.
Checked against the public recordLast updated Jan 2, 2026 · Source: ClinicalTrials.gov
The study is currently accepting participants.
Interventional
Locations may change over time.
Study sponsor
What this study is about
- Purpose
- Diagnostic
- Study type
- Interventional
- Phase
- Phase 2
- Sponsor
- Sean Fain
- Interventions being studied
- Drug: Xenon MRI; Diagnostic Test: Pulmonary Function Testing; Other: Quality of Life Questionnaire; Other: Medical Research Council Dyspnea score; Other: St. George's Respiratory Questionnaire; Diagnostic Test: Blood Biomarkers
How this study is categorized
These labels come from structured fields and exact terms in the public record.
Who may be able to participate
The sponsor separates these requirements into two groups. You do not need to interpret them alone—use them to guide a conversation with the study team.
Subjects must meet all of the following inclusion criteria to be eligible for enrollment into the trial 1. Aged 18-80 years 2. Willing and able to provide informed consent and adhere to visit/protocol schedules (Consent must be given before any study procedures are performed.) 3. Clinical diagnosis of lung cancer made by a board-certified oncologist with intent to treat with stereotactic body radiation therapy. We will not exclude individuals based on cancer type or severity of disease with the exception of the below criteria
Subjects presenting with any of the following will not be included in the trial: 1. Subject is less than 18 years old or incarcerated 2. MRI is contraindicated based on responses to MRI screening questionnaire 3. Subject is pregnant or lactating 4. Resting oxygen saturation \<90% on supplemental oxygen 5. Respiratory illness of bacterial or viral etiology within 30 days of planned treatment 6. Subject has history of any known ventricular cardiac arrhythmia 7. Subject has history of cardiac arrest within the last year 8. Subject has prior history of cancer treatment with radiation therapy to the lung 9. Subject has concurrent cancer treatment with agents associated with increased risk of radiation pneumonitis (e.g. immunotherapy, chemotherapy) 10. Subject does not fit into 129Xe vest coil used for MRI 11. Subject cannot hold his/her breath for 15 seconds 12. Subject deemed unlikely to be able to comply with instructions during imaging 13. Medical or psychological conditions which, in the opinion of the investigator, might create undue risk to the subject or interfere with the subject's ability to comply with the protocol requirements
Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.
U.S. locations
- University of IowaIowa City, Iowa
Source and freshness
Processed from ClinicalTrials.gov. Last public update: Jan 2, 2026. Always confirm current availability with the study team.