Definitive Radiation for High-Risk Spine Metastases

Study summary

This study is looking at whether patients with cancer that has aggressively spread to the spine can be treated with stereotactic body radiation therapy only and avoid a large spine surgery

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Key things to know

Main goalTreatment

This describes the study’s primary purpose.

What is being studiedSBRT to the spine

The study team can explain what participation involves.

Who it may be forMetastatic or stage IV

These are broad labels—not an eligibility decision.

Checked against the public recordLast updated May 14, 2025 · Source: ClinicalTrials.gov

Is enrollment open?Recruiting

The study is currently accepting participants.

What kind of study?Phase 2

Interventional

Where is it offered?1 U.S. location

Locations may change over time.

Who runs it?Stony Brook University

Study sponsor

Study overview

What this study is about

Purpose: Treatment
Study type: Interventional
Phase: Phase 2
Sponsor: Stony Brook University
Interventions being studied: Radiation: SBRT to the spine

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How this study is categorized

These labels come from structured fields and exact terms in the public record.

Disease setting

Metastatic or stage IV→

Treatment approach

Radiation therapy→Surgery→

Public criteria

Who may be able to participate

The sponsor separates these requirements into two groups. You do not need to interpret them alone—use them to guide a conversation with the study team.

Requirements people may need to meetInclusion criteria

Eligible patients must have:
Any pathologically proven solid tumor diagnosis not of central nervous system origin with radiographic or pathologic evidence of metastatic disease
Metastatic spine involvement documented by imaging
Involvement of maximum 3 contiguous vertebral bodies at the index site
Intact neurologic function, or only minor neurologic deficits with muscle strength greater or equal to 4 out of 5 with or without steroids
An evaluation by an radiation oncology and orthopedic spine/neurosurgery attending
ECOG Performance Status of 0-3 Patients are ineligible if they have:
An unstable spine defined as a Spinal Instability Neoplastic Score (SINS) greater than 12
Had previous surgery or radiation to address the target spinal metastases
Radiosensitive tumors (e.g. small cell lung cancer, lymphoma, multiple myeloma, and germ-cell tumors)

Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.

Study sites

U.S. locations

Stony Brook University HospitalStony Brook, New York

Source and freshness
Processed from ClinicalTrials.gov. Last public update: May 14, 2025. Always confirm current availability with the study team.

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