Phase I Study of Autologous CD8+ and CD4+ Engineered T Cell Receptor T Cells in Subjects With Advanced or Metastatic Solid Tumor

Key Inclusion Criteria: 1. Confirmed KRAS G12V mutational status and HLA-A\*11:01 allele 2. Histologically confirmed advanced or metastatic, unresectable solid tumor 3. Progressed on or intolerant of at least one prior line of standard systemic therapy for the current malignancy. 4. Measurable disease per RECIST v1.1. 5. ECOG performance status 0-1 6. Adequate organ and bone marrow function Key Exclusion Criteria: 1. Any systemic cytotoxic chemotherapy, investigational agents, or any anti-tumor drug from a previous treatment regimen or clinical study (including small molecules and I/O compounds) within 5 half-lives or 14 days of Screening, whichever is shorter. 2. Any prior gene therapy utilizing an integrating vector 3. Previous allogeneic stem cell transplantation or prior organ transplantation 4. History of treated primary immunodeficiency, autoimmune, or inflammatory disease including inflammatory bowel disease, systemic lupus erythematosus, rheumatoid arthritis, myasthenia gravis, or Grave's disease 5. Primary brain tumor 6. Untreated central nervous system (CNS) metastatic disease, leptomeningeal disease, or cord compression. 7. Uncontrolled active bacterial, viral, fungal, or mycobacterial infection 8. Pregnant or lactating subjects 9. Surgery or catheter-based interventions 10. Previously identified allergy, hypersensitivity, or known contraindication to cyclophosphamide, fludarabine, or any other agent associated with lymphodepleting chemotherapy (LDC) or AFNT-211 product 11. Uncontrolled significant intercurrent or recent illness 12. Diagnosis of another malignancy within 2 years prior to screening. 13. Seropositive for hepatitis B surface antigen (HBsAg) and/or hepatitis B core antibody (HBcAb) 14. Seropositive for hepatitis C antibody. 15. Known human immunodeficiency virus (HIV) infection