Study to Compare Furmonertinib to Platinum-Based Chemotherapy for Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations (FURVENT)
Global, Phase 3, randomized, multicenter, open-label study evaluating the efficacy and safety of furmonertinib (firmonertinib) at 2 dose levels (160 mg once daily \[QD\] and 240 mg QD) compared to platinum-based chemotherapy in previously untreated patients with locally advanced or metastatic non-squamous Non-Small Cell Lung Cancer (NSCLC) with Epidermal Growth Factor Receptor (EGFR) exon 20 insertion mutations. A target of approximately 375 patients will be randomized in a 1:1:1 ratio to treatment with furmonertinib 240 mg QD, furmonertinib 160 mg QD, or platinum-based chemotherapy.
Checked against the public recordLast updated Jun 22, 2025 · Source: ClinicalTrials.gov
What this study is about
- Purpose
- Treatment
- Study type
- Interventional
- Phase
- Phase 3
- Sponsor
- ArriVent BioPharma, Inc.
- Interventions being studied
- Drug: furmonertinib 240 mg oral, daily; Drug: furmonertinib 160 mg oral, daily; Drug: platinum-based chemotherapy
How this study is categorized
These labels come from structured fields and exact terms in the public record.
Who may be able to participate
Key Inclusion Criteria: * Histologically or cytologically documented, locally advanced or metastatic non-squamous Non-Small Cell Lung Cancer (NSCLC) not amenable to curative surgery or radiotherapy. * Documented results of the presence of an Epidermal Growth Factor Receptor (EGFR) exon 20 insertion mutation in tumor tissue or blood from local or central testing. * No prior systemic anticancer therapy regimens received for locally advanced or metastatic Non-Small Cell Lung Cancer (NSCLC) including prior treatment with any Epidermal Growth Factor Receptor (EGFR)-targeting agents (e.g., previous (EGFR) TKIs, monoclonal antibodies, or bispecific antibodies). * Patients who have received prior neo-adjuvant and/or adjuvant chemotherapy, immunotherapy, or chemo radiotherapy for non-metastatic disease (excluding EGFR-TKIs) must have experienced a treatment free interval of at least 12 months. * Patients with a history of treated CNS metastases or new asymptomatic CNS metastases are eligible.
Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.
U.S. locations
- Arrivent Investigative SiteDaphne, Alabama
- Arrivent Investigative SiteYuma, Arizona
- Arrivent Investigative SiteFayetteville, Arkansas
- Arrivent Investigative SiteBeverly Hills, California
- Arrivent Investigative SiteFullerton, California
- Arrivent Investigative SiteLong Beach, California
- Arrivent Investigative SiteLos Alamitos, California
- Arrivent Investigative SiteNapa, California
- Arrivent Investigative SiteOrange, California
- Arrivent Investigative SiteOrange, California
- Arrivent Investigative siteSacramento, California
- Arrivent Investigative SiteSan Diego, California
Source and freshness
Processed from ClinicalTrials.gov. Last public update: Jun 22, 2025. Always confirm current availability with the study team.