Active Not RecruitingPhase 3NCT05607550

Study to Compare Furmonertinib to Platinum-Based Chemotherapy for Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations (FURVENT)

Global, Phase 3, randomized, multicenter, open-label study evaluating the efficacy and safety of furmonertinib (firmonertinib) at 2 dose levels (160 mg once daily \[QD\] and 240 mg QD) compared to platinum-based chemotherapy in previously untreated patients with locally advanced or metastatic non-squamous Non-Small Cell Lung Cancer (NSCLC) with Epidermal Growth Factor Receptor (EGFR) exon 20 insertion mutations. A target of approximately 375 patients will be randomized in a 1:1:1 ratio to treatment with furmonertinib 240 mg QD, furmonertinib 160 mg QD, or platinum-based chemotherapy.

Checked against the public recordLast updated Jun 22, 2025 · Source: ClinicalTrials.gov

StatusActive Not Recruiting
PhasePhase 3
U.S. locations208
SponsorArriVent BioPharma, Inc.
01
Study overview

What this study is about

Purpose
Treatment
Study type
Interventional
Phase
Phase 3
Sponsor
ArriVent BioPharma, Inc.
Interventions being studied
Drug: furmonertinib 240 mg oral, daily; Drug: furmonertinib 160 mg oral, daily; Drug: platinum-based chemotherapy
02
Explore related studies

How this study is categorized

These labels come from structured fields and exact terms in the public record.

03
Public criteria

Who may be able to participate

Key Inclusion Criteria: * Histologically or cytologically documented, locally advanced or metastatic non-squamous Non-Small Cell Lung Cancer (NSCLC) not amenable to curative surgery or radiotherapy. * Documented results of the presence of an Epidermal Growth Factor Receptor (EGFR) exon 20 insertion mutation in tumor tissue or blood from local or central testing. * No prior systemic anticancer therapy regimens received for locally advanced or metastatic Non-Small Cell Lung Cancer (NSCLC) including prior treatment with any Epidermal Growth Factor Receptor (EGFR)-targeting agents (e.g., previous (EGFR) TKIs, monoclonal antibodies, or bispecific antibodies). * Patients who have received prior neo-adjuvant and/or adjuvant chemotherapy, immunotherapy, or chemo radiotherapy for non-metastatic disease (excluding EGFR-TKIs) must have experienced a treatment free interval of at least 12 months. * Patients with a history of treated CNS metastases or new asymptomatic CNS metastases are eligible.

Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.

04
Study sites

U.S. locations

  • Arrivent Investigative SiteDaphne, Alabama
  • Arrivent Investigative SiteYuma, Arizona
  • Arrivent Investigative SiteFayetteville, Arkansas
  • Arrivent Investigative SiteBeverly Hills, California
  • Arrivent Investigative SiteFullerton, California
  • Arrivent Investigative SiteLong Beach, California
  • Arrivent Investigative SiteLos Alamitos, California
  • Arrivent Investigative SiteNapa, California
  • Arrivent Investigative SiteOrange, California
  • Arrivent Investigative SiteOrange, California
  • Arrivent Investigative siteSacramento, California
  • Arrivent Investigative SiteSan Diego, California

Source and freshness
Processed from ClinicalTrials.gov. Last public update: Jun 22, 2025. Always confirm current availability with the study team.

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