Study of the Efficacy and Safety of Ponsegromab in Patients With Cancer, Cachexia and Elevated GDF-15
Study to evaluate the efficacy, safety and tolerability of ponsegromab compared to placebo in patients with cancer, cachexia, and elevated GDF 15.
Checked against the public recordLast updated Jun 3, 2026 · Source: ClinicalTrials.gov
What this study is about
- Purpose
- Treatment
- Study type
- Interventional
- Phase
- Phase 2
- Sponsor
- Pfizer
- Interventions being studied
- Drug: ponsegromab; Drug: Placebo for ponsegromab
How this study is categorized
These labels come from structured fields and exact terms in the public record.
Who may be able to participate
Key Inclusion Criteria: * Documented active diagnosis of non-small cell lung, pancreatic, colorectal cancer * Cachexia defined by Fearon criteria of weight loss * Serum GDF-15 concentrations * Signed informed consent * ECOG PS ≤3 with life expectancy of at least 4 months to be able to complete Part A. Key Exclusion Criteria: * Receiving tube feedings or parenteral nutrition at the time of Screening or Randomization. * Current active reversible causes of decreased food intake. * Cachexia caused by other reasons. * History of allergic or anaphylactic reaction to any therapeutic or diagnostic monoclonal antibody. * inadequate liver function * renal disease requiring dialysis
Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.
U.S. locations
- CARTI ConwayConway, Arkansas
- CARTI Cancer CenterLittle Rock, Arkansas
- CARTI North Little RockNorth Little Rock, Arkansas
- CARTI StuttgartStuttgart, Arkansas
- Pacific Cancer Medical Center INCAnaheim, California
- Beverly Hills Cancer CenterBeverly Hills, California
- Emad Ibrahim,MD,INC.Redlands, California
- Providence Medical FoundationSanta Rosa, California
- IU Health Arnett Cancer CenterLafayette, Indiana
- Pennington Biomedical Research CenterBaton Rouge, Louisiana
- Tandem Clinical ResearchMarrero, Louisiana
- Bozeman Health Deaconess HospitalBozeman, Montana
Source and freshness
Processed from ClinicalTrials.gov. Last public update: Jun 3, 2026. Always confirm current availability with the study team.