TerminatedNot applicableNCT05299606

POWER Study (Prospective Transbronchial Microwave + Robotic-Assisted Bronchoscopy)

This is a prospective, multicenter, single-arm study on transbronchial microwave ablation using the NEUWAVE FLEX Microwave Ablation System and Accessories on oligometastatic tumors in the peripheral lung, guided by the Auris MONARCH Platform for visualization and access while using cone beam CT (computed tomography) to confirm probe tip placement and final ablation zone. The primary endpoint is Technique Efficacy, assessed 30-days post-ablation via CT imaging.

Checked against the public recordLast updated Nov 24, 2025 · Source: ClinicalTrials.gov

StatusTerminated
PhaseNot applicable
U.S. locations10
SponsorEthicon, Inc.
01
Study overview

What this study is about

Purpose
Treatment
Study type
Interventional
Phase
Not applicable
Sponsor
Ethicon, Inc.
Interventions being studied
Device: Transbronchial Microwave Ablation
02
Explore related studies

How this study is categorized

These labels come from structured fields and exact terms in the public record.

03
Public criteria

Who may be able to participate

INCLUSION CRITERIA: * Signed informed consent. * Subjects greater or equal to 22 years old. * Performance status 0-2 (Eastern Cooperative Oncology Group classification (ECOG). * Willing to fulfill all follow-up visit requirements. * Subjects with at least one oligometastatic lung tumor where the primary tumor is controlled (in the opinion of the investigator or treating oncologist). * Oligometastatic lung tumor(s) planned to be ablated in the outer two-thirds of the lung and not closer than 1cm to the pleura. EXCLUSION CRITERIA: * Pregnant or breastfeeding. * Subjects with thoracic implantable devices, including pacemakers or other electronic implants. * Chronic, continuous ventilator support, which uses bi-level positive airway pressure (PAP) to improve lung function for severe conditions. (However, intermittent PAP, for non-pulmonary conditions, such as sleep apnea, is permitted). * Prior pneumonectomy. * Severe bronchiectasis (with FEV1 \<30%) or disease deemed to be too severe in the opinion of the investigator. * Platelet count ≤ 50,000/mm3. * Subjects with uncorrectable coagulopathy at time of screening. * Subjects medically unable to stop anti-platelet agents (e.g., aspirin, clopidogrel, prasugrel, ticagrelor) at least 5 days prior to the procedure through 48-72 hours after the procedure. * Subjects medically unable to stop warfarin at least 3-5 days prior to the ablation procedure, or until INR \< 1.5, through 48-72 hours after the procedure. On the day of the procedure, subjects with an INR \> 1.5 cannot have the procedure completed that day but may be rescheduled or postponed. * Subjects medically unable to stop anticoagulants (e.g., rivaroxaban, apixaban, dabigatran, endoxaban) at least 3 days prior to the ablation procedure through 48-72 hours after the procedure. * Expected survival less than 6 months in the opinion of the investigator and/or treating oncologist. * Subjects with known or suspected brain metastases. * Subject has had any radiation (i.e., SBRT or EBRT) to the intended ablation zone. * Endobronchial tumors proximal to and including the segmental airways. * Lung ablation, surgical resection therapy, radiotherapy, or any other treating procedure within 30 days prior to the planned study ablation procedure or those who plan to receive a lung ablation, surgical resection, or radiation therapy on the ablated lung side before completing the primary endpoint assessment (30 days post-ablation). * Systemic therapy (e.g., chemotherapy, targeted drug therapy, or immunotherapy) within 14 days prior to the planned study ablation procedure or those who plan to receive systemic therapy before completing the primary endpoint assessment (30 days post-ablation).

Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.

04
Study sites

U.S. locations

  • Stanford University School of MedicineStanford, California
  • UCONN HealthFarmington, Connecticut
  • Minnesota Lung CenterMinneapolis, Minnesota
  • FirstHealth Moore Regional HospitalPinehurst, North Carolina
  • Cleveland ClinicCleveland, Ohio
  • University of PennsylvaniaPhiladelphia, Pennsylvania
  • MD AndersonHouston, Texas
  • University of TorontoToronto, Ontario
  • Centre Hospitalier de l'Universite de MontrealMontreal, Quebec
  • Prince of Wales HospitalShatin

Source and freshness
Processed from ClinicalTrials.gov. Last public update: Nov 24, 2025. Always confirm current availability with the study team.

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