Liquid Biopsy With PET/CT Versus PET/CT Alone in Diagnosis of Small Lung Nodules
The purpose of this study is to determine if a liquid biopsy, a method of detecting cancer from a blood draw, combined with a PET/CT scan, a type of radiological scan, is better at determining whether a lung nodule is cancerous when compared to a PET/CT scan alone. A PET/CT scan is already used for diagnosis of lung nodules, but its efficacy is uncertain in nodules 6-20 mm in size. Therefore, the PET/CT will be evaluated for its diagnostic ability in lesions this size alone and in combination with a liquid biopsy. Secondarily, a machine learning model will be created to see if the combination of the PET/CT imaging data and the liquid biopsy data can predict the presence of cancer.
Checked against the public recordLast updated Dec 8, 2023 · Source: ClinicalTrials.gov
What this study is about
- Purpose
- Not specified
- Study type
- Observational
- Phase
- Not applicable
- Sponsor
- Palo Alto Veterans Institute for Research
- Interventions being studied
- Not specified
How this study is categorized
These labels come from structured fields and exact terms in the public record.
Who may be able to participate
Inclusion Criteria: * Over 18 years of age * ECOG performance status of 0,1, or 2 * Newly discovered lung nodule with: 1. At least one solid lung nodule measuring 6 mm- 20 mm in greatest diameter detected on screening CT 2. No single lesion larger than 20 mm in greatest diameter when multiple nodules present 3. High- or intermediate-risk nodules per American College of Chest Physician (ACCP) guidelines * Able to provide informed consent Exclusion Criteria: * Prior cancer of any type for the previous 3 years * Prior organ, bone marrow, of hematopoietic stem cell transplant * Contraindication to administration of \[18F\]FDG * Inability to undergo a PET/CT scan * Ongoing infection, either acute or subacute * Severe COPD or lung disease requiring home oxygen use * Pregnancy
Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.
U.S. locations
- VA Palo Alto Health Care SystemPalo Alto, California
Source and freshness
Processed from ClinicalTrials.gov. Last public update: Dec 8, 2023. Always confirm current availability with the study team.