ROSE for Improved Molecular Marker Testing Via EBUS
This research study is being done to compare two ways to conduct bronchoscopic biopsy of lymph nodes and other structures in the chest (i.e. the presence or absence of an on-site cytotechnologist performing a limited microscopic evaluation to provide non-binding feedback on specimen adequacy in real time during the procedure).
Checked against the public recordLast updated Dec 17, 2025 · Source: ClinicalTrials.gov
What this study is about
- Purpose
- Other
- Study type
- Interventional
- Phase
- Not applicable
- Sponsor
- Johns Hopkins University
- Interventions being studied
- Other: ROSE (presence of cytotech) & liquid prep; Other: NO-ROSE (absence of cytotech) & liquid prep; Other: ROSE (presence of cytotech) & tissue clot sample; Other: NO-ROSE (absence of cytotech) & tissue clot sample
How this study is categorized
These labels come from structured fields and exact terms in the public record.
Who may be able to participate
Inclusion Criteria: * Inpatients or outpatients \>18 years old * Capable of informed consent * Known or suspected non-small cell lung cancer (NSCLC) * Referred to the interventional pulmonary team at Johns Hopkins Hospital (JHH), Johns Hopkins Bayview Medical Center (JHBMC), or other participating sites for tissue sampling of a hilar/mediastinal lymph node or another lesion accessible by convex-probe (CP) EBUS Exclusion Criteria: * Refuse participation * Standard contraindications to EBUS and bronchoscopy in general: bleeding disorders, antiplatelet or anticoagulant usage, high fraction of inspired oxygen (FiO2) requirement, and clinical instability * Pregnant women * Cytotechnologist not available at the time of screening, enrollment, or randomization
Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.
U.S. locations
- Northwestern MedicineChicago, Illinois
- Johns Hopkins Bayview Medical CenterBaltimore, Maryland
- Johns Hopkins HospitalBaltimore, Maryland
- The Medical University of South Carolina (MUSC)Charleston, South Carolina
Source and freshness
Processed from ClinicalTrials.gov. Last public update: Dec 17, 2025. Always confirm current availability with the study team.