Study to Compare the Effects of Repeated Doses of an Investigational New Drug and a Placebo on Appetite in Advanced Cancer and Anorexia

Key Inclusion Criteria: * Documented diagnosis of non-small cell lung, pancreatic, colorectal, prostate, breast or ovarian cancer which, in the treating oncologist's assessment, is considered advanced. * Anorexia as defined by a score of ≤5 in the Cancer-Related Cachexia Symptom Assessment Appetite 7-day recall scale * Meets any of the following criteria at Randomization: * Not currently receiving antineoplastic therapy * On standard of care systemic antineoplastic therapy or treatment without curative intent * Signed informed consent. Key Exclusion Criteria: * Receiving tube feedings or parenteral nutrition at the time of Screening or Randomization. * Current active reversible causes of decreased food intake. * Current, severe gastrointestinal disease * Participants with known symptomatic brain metastases requiring steroids. * Active uncontrolled bacterial, fungal, or viral infection, including HBV, HCV, HIV or participants with known AIDS-related illness * inadequate renal or liver function. * Women who are pregnant or breast-feeding