A Study to Evaluate AB308 in Combination With AB122 in Participants With Advanced Malignancies
This is a Phase 1/1b, multicenter, open-label, dose-escalation, and dose-expansion study to evaluate the safety, tolerability, pharmacokinetic (PK), pharmacodynamic (PD), and clinical activity of AB308 in combination with zimberelimab (AB122) in participants with advanced malignancies.
Checked against the public recordLast updated Aug 28, 2025 · Source: ClinicalTrials.gov
What this study is about
- Purpose
- Treatment
- Study type
- Interventional
- Phase
- Phase 1
- Sponsor
- Arcus Biosciences, Inc.
- Interventions being studied
- Drug: AB308; Drug: Zimberelimab
How this study is categorized
These labels come from structured fields and exact terms in the public record.
Who may be able to participate
Inclusion Criteria: * Capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol. * Male or female participants ≥ 18 years of age (or age ≥ regionally approved age of consent for participation in investigational clinical studies) at the time of signing the informed consent. * Contraceptive use by men and women should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies. * Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1 * Adequate organ and marrow function Exclusion Criteria: * History of trauma or major surgery within 28 days prior to the first dose of study treatment. * Prior treatment with an anti-TIGIT antibody. * Any active or prior autoimmune disease that required treatment within 3 years of the first dose of study treatment. * Prior chemotherapy, targeted small-molecule therapy, immunotherapy, or biologic agents, or use of other investigational drugs within 28 days before first dose of study treatment. * Discontinued prior immunotherapy for immune related adverse events with a high severity. NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.
Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.
U.S. locations
- UCLA Department of Medicine - Hematology/OncologyLos Angeles, California
- Mayo Clinic Jacksonville - PPDSJacksonville, Florida
- Goshen Health SystemGoshen, Indiana
- Holden Comprehensive Cancer CenterIowa City, Iowa
- Norton Cancer Insititute-DowntownLouisville, Kentucky
- Mayo Clinic RochesterRochester, Minnesota
- Columbia University Medical CenterNew York, New York
- Ohio State University Comprehensive Cancer CenterColumbus, Ohio
- University of Oklahoma Peggy and Charles Stephenson Cancer CenterOklahoma City, Oklahoma
- University of Pittsburgh Medical CenterPittsburgh, Pennsylvania
- Tennessee Onocology - NashvilleNashville, Tennessee
- START South Texas Accelerated Research TherapeuticsSan Antonio, Texas
Source and freshness
Processed from ClinicalTrials.gov. Last public update: Aug 28, 2025. Always confirm current availability with the study team.