CAB-AXL-ADC Safety and Efficacy Study in Adults With NSCLC
The objective of this study is to assess safety and efficacy of CAB-AXL-ADC in NSCLC
Checked against the public recordLast updated Sep 25, 2025 · Source: ClinicalTrials.gov
What this study is about
- Purpose
- Treatment
- Study type
- Interventional
- Phase
- Phase 2
- Sponsor
- BioAtla, Inc.
- Interventions being studied
- Biological: CAB-AXL-ADC; Biological: PD-1 inhibitor
How this study is categorized
These labels come from structured fields and exact terms in the public record.
Who may be able to participate
Inclusion Criteria: * Patients must have measurable disease. * Age ≥ 18 years * Adequate renal function * Adequate liver function * Adequate hematological function * Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. * Life expectancy of at least three months. Exclusion Criteria: * Patients must not have clinically significant cardiac disease. * Patients must not have known non-controlled CNS metastasis. * Patients must not have had prior therapy with a conjugated or unconjugated auristatin derivative/vinca-binding site targeting payload. * Patients must not have a history of ≥ Grade 3 allergic reactions to mAb therapy as well as known or suspected allergy or intolerance to any agent given during this study. * Patients must not have had major surgery within 4 weeks before first BA3011 * Patients must not have known human immunodeficiency virus (HIV) infection, active hepatitis B and/or hepatitis C. * Patients must not be women who are pregnant or breast feeding.
Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.
U.S. locations
- City of Hope - DuarteDuarte, California
- University of California Irvine Medical Center (UCIMC) - Chao Family Comprehensive Cancer CenterIrvine, California
- California Research InstituteLos Angeles, California
- USC NorrisLos Angeles, California
- Cedars-SinaiLos Angeles, California
- University of California, San Diego (UCSD) - Moores Cancer CenterSan Diego, California
- American Institute of ResearchWhittier, California
- University of Colorado Anschutz Medical CampusAurora, Colorado
- Florida Cancer Specialists & Research InstituteFleming Island, Florida
- Florida Cancer Specialists & Research InstituteFort Myers, Florida
- Florida Cancer SpecialistSt. Petersburg, Florida
- Moffitt Cancer CenterTampa, Florida
Source and freshness
Processed from ClinicalTrials.gov. Last public update: Sep 25, 2025. Always confirm current availability with the study team.