Lung Cancer Risk and Early Detection in Firefighters

Study summary

This study will evaluate whether LDCT findings differ between firefighters and non-fighters, the relationship between occupational exposures and LDCT findings, and whether a proteomics assay can further risk-stratify screen-detected nodules among a study population of 850 current and retired firefighters and 1,120 matched controls.

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Key things to know

Main goalScreening

This describes the study’s primary purpose.

What is being studiedLow Dose CT

The study team can explain what participation involves.

Who it may be forLung Cancer · Lung Diseases

These are broad labels—not an eligibility decision.

Checked against the public recordLast updated Nov 24, 2025 · Source: ClinicalTrials.gov

Is enrollment open?Completed

Ask the study team to confirm whether enrollment is open.

What kind of study?Not applicable

Interventional

Where is it offered?1 U.S. location

Locations may change over time.

Who runs it?Massachusetts General Hospital

Study sponsor

Study overview

What this study is about

Purpose: Screening
Study type: Interventional
Phase: Not applicable
Sponsor: Massachusetts General Hospital
Interventions being studied: Diagnostic Test: Low Dose CT

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How this study is categorized

These labels come from structured fields and exact terms in the public record.

Public criteria

Who may be able to participate

The sponsor separates these requirements into two groups. You do not need to interpret them alone—use them to guide a conversation with the study team.

Requirements people may need to meetInclusion criteria

40-80 years of age or with 10 years of firefighting experience
Current or retired firefighters
No personal history of lung cancer
Willing and able to receive LDCT screening at MGH or who have been screened via LDCT within the past year at MGH or another institution, and are willing to release their images to the study

Reasons someone may not be able to joinExclusion criteria

Any active cancer (undergoing treatment or diagnosed within the past 5 years)

Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.

Study sites

U.S. locations

Massachusetts General HospitalBoston, Massachusetts

Source and freshness
Processed from ClinicalTrials.gov. Last public update: Nov 24, 2025. Always confirm current availability with the study team.

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