Bronchoscopic Cryo-Immunotherapy of Lung Cancer

Inclusion Criteria: * Peripheral lung tumor on pre-procedure chest CT scan, which is known or suspected to be advanced, inoperable non-small cell lung cancer (stages IIIA/B/C and IVA/B) based on the 8th edition TNM staging guidelines * Pre-procedure chest CT scan with the presence of a bronchus or airway path leading directly to the peripheral lung tumor (also known as a "bronchus sign") * Undergoing bronchoscopy for diagnostic and/or palliative purpose unrelated to this study. * Documentation of non-small cell lung cancer either prior to procedure or via on-site pathology review during bronchoscopy (prior to proceeding with planned BCI) * Ability to provide informed consent * Concomitant chemotherapy, immunotherapy, and/or radiation therapy are allowed * ECOG performance status less than or equal to 2 Exclusion Criteria: * Pregnancy * Currently on a platelet inhibitor (such as Clopidogrel) other than aspirin or NSAIDS, or on a blood thinner (such as heparin, enoxaparin, or a novel oral anticoagulant), which is unable to be held for planned bronchoscopy * INR \>= 1.5 (post correction) * Platelets =\< 100,000 (post correction) * Bleeding diathesis * Contraindication to bronchoscopy * Absence of tissue diagnosis of non-small cell lung cancer either prior to procedure or during on-site pathology review at time of bronchoscopy.