CompletedPhase 3NCT03976362

A Study of Pembrolizumab (MK-3475) With or Without Maintenance Olaparib in First-line Metastatic Squamous Non-small Cell Lung Cancer (NSCLC, MK-7339-008/KEYLYNK-008)

The current study will compare pembrolizumab (MK-3475) plus maintenance olaparib, vs. pembrolizumab plus maintenance olaparib placebo for the treatment of squamous NSCLC. The study's 2 primary hypotheses are: 1. Pembrolizumab plus maintenance olaparib is superior to pembrolizumab plus maintenance olaparib placebo with respect to progression-free survival (PFS) per RECIST 1.1 by blinded independent clinical review (BICR). 2. Pembrolizumab plus maintenance olaparib is superior to pembrolizumab plus maintenance olaparib placebo with respect to overall survival (OS). As of Amendment 07, there will be no further analyses for OS and patient-reported outcome assessments.

Checked against the public recordLast updated Feb 25, 2026 · Source: ClinicalTrials.gov

StatusCompleted
PhasePhase 3
U.S. locations178
SponsorMerck Sharp & Dohme LLC
01
Study overview

What this study is about

Purpose
Treatment
Study type
Interventional
Phase
Phase 3
Sponsor
Merck Sharp & Dohme LLC
Interventions being studied
Biological: Pembrolizumab; Drug: Carboplatin; Drug: Paclitaxel; Drug: Nab-paclitaxel; Drug: Olaparib; Drug: Placebo
02
Explore related studies

How this study is categorized

These labels come from structured fields and exact terms in the public record.

03
Public criteria

Who may be able to participate

Inclusion Criteria: 1. Have a histologically or cytologically confirmed diagnosis squamous NSCLC. 2. Have Stage IV squamous NSCLC. 3. Have measurable disease based on RECIST 1.1. 4. Have not received prior systemic treatment for their advanced/metastatic NSCLC. 5. Have provided archival tumor tissue sample or newly obtained core or incisional biopsy of a tumor lesion not previously irradiated. Note: Adequacy of biopsy specimen for the above analyses must be confirmed by the central laboratory before the participant can receive study intervention(s). Submission of another tumor specimen may be required prior to enrolling the participant, if adequate tumor tissue was not provided the first time. 6. Have a performance status of 0 or 1 on the Eastern Cooperative Oncology Group (ECOG) Performance Status assessed within 7 days prior to the administration of study intervention 7. Have a life expectancy of at least 3 months. 8. Has adequate organ function. 9. Male and female participants who are not pregnant and of childbearing potential must follow contraceptive guidance during the treatment period and for 180 days afterwards. 10. Male participants must refrain from donating sperm during the treatment period and for 180 days afterwards. Exclusion Criteria: 1. Has non-squamous histology NSCLC. 2. Has a known additional malignancy that is progressing or has progressed within the past 3 years requiring active treatment. 3. Has known active central nervous system metastases and/or carcinomatous meningitis. 4. Has a known hypersensitivity to any components or excipients of carboplatin, paclitaxel or nab-paclitaxel, or olaparib. 5. Has a severe hypersensitivity (≥Grade 3) to pembrolizumab and/or any of its excipients. 6. Has an active autoimmune disease that has required systemic treatment in past 2 years. 7. Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy. 8. Has a known history of human immunodeficiency virus (HIV) infection, a known history of hepatitis B infection, or known active hepatitis C virus infection. 9. Has interstitial lung disease, or history of pneumonitis requiring systemic steroids for treatment. 10. Has received prior therapy with olaparib or with any other polyadenosine 5' diphosphoribose (polyADP ribose) polymerization (PARP) inhibitor. 11. Has received prior therapy with an agent directed to programmed cell death ligand 1 (PD-L1), anti PD-L2, or directed to a stimulatory or co-inhibitory T-cell receptor (e.g., cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), OX-40, CD137). 12. Has myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML) or with features suggestive of MDS/AML.

Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.

04
Study sites

U.S. locations

  • Alabama Oncology Bruno Cancer Center ( Site 0001)Birmingham, Alabama
  • Disney Family Cancer Center ( Site 0005)Burbank, California
  • Boca Raton Regional Hospital ( Site 0018)Boca Raton, Florida
  • Mid-Florida Cancer Centers ( Site 0022)Orange City, Florida
  • H. Lee Moffitt Cancer Center and Research Institute ( Site 0024)Tampa, Florida
  • Columbus Regional Research Institute ( Site 0099)Columbus, Georgia
  • Mount Sinai Hospital Medical Center ( Site 0035)Chicago, Illinois
  • Oncology of Northshore ( Site 0036)Rolling Meadows, Illinois
  • Methodists Hospitals/Premier Oncology Hematology Associates ( Site 0039)Merrillville, Indiana
  • MedStar Franklin Square Medical Center ( Site 0044)Baltimore, Maryland
  • Barbara Ann Karmanos Cancer Institute ( Site 0046)Detroit, Michigan
  • Hattiesburg Clinic ( Site 0051)Hattiesburg, Mississippi

Source and freshness
Processed from ClinicalTrials.gov. Last public update: Feb 25, 2026. Always confirm current availability with the study team.

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