CompletedPhase 2NCT03958045

Combination Rucaparib With Nivolumab in Small Cell Lung Carcinoma

The purpose of this study is to evaluate survival and response rate of the combination rucaparib and nivolumab as maintenance therapy in platinum-sensitive small cell lung carcinoma.

Checked against the public recordLast updated Oct 22, 2024 · Source: ClinicalTrials.gov

StatusCompleted
PhasePhase 2
U.S. locations1
SponsorZhonglin Hao
01
Study overview

What this study is about

Purpose
Treatment
Study type
Interventional
Phase
Phase 2
Sponsor
Zhonglin Hao
Interventions being studied
Combination Product: Rucaparib and Nivolumab
02
Explore related studies

How this study is categorized

These labels come from structured fields and exact terms in the public record.

03
Public criteria

Who may be able to participate

Inclusion Criteria * Patients with histologically or cytologically confirmed stage IV, extensive stage, small cell lung cancer who achieved either partial or complete remission per RECIST 1.1 post frontline chemotherapy with platinum doublet (Cisplatin or Carboplatin/etoposide). * Enrollment is within 6 weeks of last (4th cycle) of chemotherapy. * Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2 * Adequate Bone Marrow Function * Adequate Hepatic Function Exclusion Criteria * Prior therapy with any antibody/drug targeting T-cell co-regulatory proteins (immune checkpoints) * Major surgery within 4 weeks of initiation of study medication. * Current use of (some) immunosuppressants * Active infection requiring systemic therapy * HIV/AIDS * Hepatitis B virus or hepatitis C virus infection at screening * Autoimmune disease * Persisting toxicity related to prior therapy * Pregnancy * Vaccination (except inactive) within 4 weeks of the first dose of nivolumab * Hypersensitivity to the study drugs * Cardiovascular disease * Untreated central nervous system (CNS) metastases or leptomeningeal carcinomatosis * (Some) active secondary malignancy * Active pneumonitis or interstitial lung disease

Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.

04
Study sites

U.S. locations

  • Markey Cancer Center, University of KentuckyLexington, Kentucky

Source and freshness
Processed from ClinicalTrials.gov. Last public update: Oct 22, 2024. Always confirm current availability with the study team.

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