Combination Rucaparib With Nivolumab in Small Cell Lung Carcinoma
The purpose of this study is to evaluate survival and response rate of the combination rucaparib and nivolumab as maintenance therapy in platinum-sensitive small cell lung carcinoma.
Checked against the public recordLast updated Oct 22, 2024 · Source: ClinicalTrials.gov
What this study is about
- Purpose
- Treatment
- Study type
- Interventional
- Phase
- Phase 2
- Sponsor
- Zhonglin Hao
- Interventions being studied
- Combination Product: Rucaparib and Nivolumab
How this study is categorized
These labels come from structured fields and exact terms in the public record.
Who may be able to participate
Inclusion Criteria * Patients with histologically or cytologically confirmed stage IV, extensive stage, small cell lung cancer who achieved either partial or complete remission per RECIST 1.1 post frontline chemotherapy with platinum doublet (Cisplatin or Carboplatin/etoposide). * Enrollment is within 6 weeks of last (4th cycle) of chemotherapy. * Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2 * Adequate Bone Marrow Function * Adequate Hepatic Function Exclusion Criteria * Prior therapy with any antibody/drug targeting T-cell co-regulatory proteins (immune checkpoints) * Major surgery within 4 weeks of initiation of study medication. * Current use of (some) immunosuppressants * Active infection requiring systemic therapy * HIV/AIDS * Hepatitis B virus or hepatitis C virus infection at screening * Autoimmune disease * Persisting toxicity related to prior therapy * Pregnancy * Vaccination (except inactive) within 4 weeks of the first dose of nivolumab * Hypersensitivity to the study drugs * Cardiovascular disease * Untreated central nervous system (CNS) metastases or leptomeningeal carcinomatosis * (Some) active secondary malignancy * Active pneumonitis or interstitial lung disease
Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.
U.S. locations
- Markey Cancer Center, University of KentuckyLexington, Kentucky
Source and freshness
Processed from ClinicalTrials.gov. Last public update: Oct 22, 2024. Always confirm current availability with the study team.