Analysis of Biopsy Specimens to Study Responses to PD-1 or PD-L1 Therapies
The purpose of this study is to attempt to obtain an on-treatment biopsy in participants with non-small cell lung cancer who are receiving standard treatment with a drug that targets the PD-1 or PD-L1 protein.
Checked against the public recordLast updated May 15, 2025 · Source: ClinicalTrials.gov
What this study is about
- Purpose
- Not specified
- Study type
- Observational
- Phase
- Not applicable
- Sponsor
- Memorial Sloan Kettering Cancer Center
- Interventions being studied
- Diagnostic Test: Pre-Treatment Biopsy; Diagnostic Test: On-Treatment Biopsy; Diagnostic Test: Biopsy at Disease Progression; Diagnostic Test: Peripheral Blood-Based Studies
How this study is categorized
These labels come from structured fields and exact terms in the public record.
Who may be able to participate
Inclusion Criteria: * Pathologically confirmed newly diagnosed or recurrent advanced Non Small Cell Lung Cancer/NSCLC that is PI-L1 high by immunohistochemistry (PD-L1 \>/= 50%) * Intended treatment with a PD-(L)1 inhibitor * Age \>/= 18 years * Karnofsky Performance Status \>/= 70% and medically fit to undergo a biopsy procedure Exclusion Criteria: * Any medical condition or any sites of disease that would preclude a biopsy * Pregnant or breastfeeding women * Cognitively impairment affecting ability to understand and provide informed consent * Prior PD-(L)1 blockade treatment * Chemotherapy within 6 months prior to enrollment
Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.
U.S. locations
- Memoral Sloan Kettering Basking Ridge (Consent and Follow up)Basking Ridge, New Jersey
- Memoral Sloan Kettering Monmouth (Consent and Follow up)Middletown, New Jersey
- Memorial Sloan Kettering Bergen (Consent and Follow up)Montvale, New Jersey
- Memorial Sloan Kettering Cancer Center @ Suffolk (Consent Only)Commack, New York
- Memoral Sloan Kettering Westchester (Consent & Follow Up)Harrison, New York
- Memorial Sloan - Kettering Cancer Center (Consent and follow-up)New York, New York
Source and freshness
Processed from ClinicalTrials.gov. Last public update: May 15, 2025. Always confirm current availability with the study team.