TerminatedEarly Phase 1NCT03870529

High Dose Vitamin A Compound in Treating Participants With Resectable Non-Small Cell Lung Cancer

This trial studies how well high dose vitamin A compound works in treating participants with non-small cell lung cancer that can be removed by surgery. Vitamin A compound may increase the number of germinal centers (immune centers that make antibodies mature) in tumor and lymph tissues which may be beneficial to patients with cancer.

Checked against the public recordLast updated Jan 9, 2024 · Source: ClinicalTrials.gov

StatusTerminated
PhaseEarly Phase 1
U.S. locations1
SponsorWake Forest University Health Sciences
01
Study overview

What this study is about

Purpose
Treatment
Study type
Interventional
Phase
Early Phase 1
Sponsor
Wake Forest University Health Sciences
Interventions being studied
Drug: Vitamin A Compound; Procedure: Therapeutic Conventional Surgery
02
Explore related studies

How this study is categorized

These labels come from structured fields and exact terms in the public record.

03
Public criteria

Who may be able to participate

Inclusion Criteria: * Patient must be 18 years of age or older. * Patients must have either biopsy proven or radiographically suspected non-small cell lung cancer. * Patients must have disease in the chest that is felt to be surgically resectable. * ECOG performance status of 0-2. * Ability to understand and the willingness to sign an IRB-approved informed consent document Exclusion Criteria: * Patients younger than 18 years of age * Women who are pregnant or breast feeding. * Patients may not be receiving any other investigational agents for the treatment of nonsmall cell lung cancer. * Patients may not be taking the following medications: high dose vitamin A supplement (multivitamin supplements prohibited only if vitamin A content is greater than 3,500 international units), bexarotene, alitretinoin, tretinoin, adapalene, isotretinoin, acitretin, doxycycline, minocycline, or demeclocycline, * Uncontrolled intercurrent illness including, but not limited to, pancreatitis, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements. * Hypervitaminosis A - toxic effects of ingesting too much vitamin A.

Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.

04
Study sites

U.S. locations

  • Wake Forest Baptist Comprehensive Cancer CenterWinston-Salem, North Carolina

Source and freshness
Processed from ClinicalTrials.gov. Last public update: Jan 9, 2024. Always confirm current availability with the study team.

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