TerminatedPhase 2NCT03862131

PROactive Evaluation of Function to Avoid CardioToxicity

This study is intended to evaluate the ability of an intramyocardial strain analysis package with cardiac MRI to assist in the early detection and management of cardiotoxicity from therapeutics used to treat cancer.

Checked against the public recordLast updated Jul 29, 2025 · Source: ClinicalTrials.gov

StatusTerminated
PhasePhase 2
U.S. locations1
SponsorWashington University School of Medicine
01
Study overview

What this study is about

Purpose
Supportive Care
Study type
Interventional
Phase
Phase 2
Sponsor
Washington University School of Medicine
Interventions being studied
Device: MyoStrain®
02
Explore related studies

How this study is categorized

These labels come from structured fields and exact terms in the public record.

03
Public criteria

Who may be able to participate

Inclusion Criteria: * Participant in the SURVIVE registry * Signed informed consent form for PROACT * Histological diagnosis of any cancer type (patients with treated and clinically stable brain metastasis are acceptable) * Scheduled to receive anti-cancer therapy (radiation therapy is permitted) Exclusion Criteria: * Contraindication to magnetic resonance imaging (MRI) * Unable to comply with study investigations (in the judgment of the investigator) * Life expectancy less than 1 year * Note: If a patient develops a temporary contraindication (e.g. temporary tissue expanders in breast cancer patients) after the baseline MRI, follow up MRIs will be discontinued for safety for the duration in which the patient has the contraindication. However, once the patient is no longer contraindicated to receiving MRIs, the study schedule may resume with their next scheduled MRI time point from the date of enrollment. Therefore, some time points may be skipped during the patient's enrollment in the study. Also, if a patient needs a repeat MRI at any time point for any reason (i.e. panic attack during the MRI causing them to not be able to continue, unreadable images, etc.), we may repeat the MRI as long as the patient is willing.

Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.

04
Study sites

U.S. locations

  • Washington University School of MedicineSt Louis, Missouri

Source and freshness
Processed from ClinicalTrials.gov. Last public update: Jul 29, 2025. Always confirm current availability with the study team.

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