An Study to Evaluate the Safety and Efficacy of Copanlisib in Combination With Nivolumab in Patients With Advanced Solid Tumors

Inclusion Criteria: * Participants with a histologically confirmed diagnosis of: Phase 1b: * Advanced solid tumors where nivolumab is indicated as per the latest nivolumab Prescribing Information, Phase 2: * Metastatic NSCLC, progressing on or after prior pembrolizumab therapy with or without chemotherapy, irrespective of PD-L1 expression Patients with EGFR or ALK genomic tumor aberrations should have disease progression on FDA-approved therapy for these aberrations. * Recurrent or metastatic HNSCC progressing on or after prior pembrolizumab therapy with or without chemotherapy * HCC progressing after any prior therapy. Exclusion Criteria: * Active, known or suspected autoimmune disease. Participants with vitiligo, type I diabetes mellitus, residual hypothyroidism due to autoimmune condition only requiring hormone replacement, psoriasis not requiring systemic treatment, or conditions not expected to recur in the absence of an external trigger are permitted to enroll. * Major surgery, open biopsy or significant traumatic injury ≤ 28 days prior to first administration of study intervention. Central line surgery is not considered major surgery * Symptomatic metastatic brain or meningeal carcinomatosis or tumors unless the participant is \> 6 months from definitive therapy (surgery or radiotherapy), has no evidence of tumor growth on an imaging study and is clinically stable with respect to the tumor at the start of study intervention. * Other malignancy within the last 5 years except for the following, which are permitted: * curatively treated basal cell/squamous cell skin cancer, * carcinoma in situ of the cervix, * superficial transitional cell bladder carcinoma (if BCG \[Bacillus Calmette-Guerin\] treatment was given, there should be a minimum of 6 months between last dose and enrollment), * in situ ductal carcinoma of the breast after complete resection, * participants with localized, resected and/or low-risk prostate cancer may be eligible after discussion with the sponsor's designated medical representative and sponsor's approval. * Other protocol inclusion/exclusion criteria may apply