Bronchoscopic Laser Ablation of Peripheral Lung Tumors
As our population ages and we diagnose early lung cancer in patients who cannot undergo surgery due to multiple medical conditions, there is growing interest in minimally invasive modalities to treat these tumors. In this study we are assessing the ability of bronchoscopic laser ablation to kill the cancer cells in these tumors. Patients will undergo bronchoscopy (a tube-like instrument inserted through the mouth to view the inside of the trachea, air passages, and lungs). A thin catheter will be passed through the wind-pipes and into the lung tumor with computed tomography guidance. A laser probe is then passed through this catheter and it is used to destroy the tumor with heat. Patients will then undergo lung surgery with resection of the tumor, and the resected specimen will be reviewed to describe the amount of tumor-kill produced by the laser.
Checked against the public recordLast updated Feb 16, 2023 · Source: ClinicalTrials.gov
What this study is about
- Purpose
- Diagnostic
- Study type
- Interventional
- Phase
- Not applicable
- Sponsor
- M.D. Anderson Cancer Center
- Interventions being studied
- Procedure: Cone-Beam Computed Tomography; Procedure: Conventional Surgery; Procedure: Laser Ablation
How this study is categorized
These labels come from structured fields and exact terms in the public record.
Who may be able to participate
Inclusion Criteria: * Written informed consent * Performance status 0-2 (Eastern Cooperative Oncology Group classification) * Subject is considered a candidate for bronchoscopy * Subject is considered a candidate for surgery (other lobar or sub-lobar resection) based on radiographic staging and functional evaluation * Lung lesion that is either biopsy-proven cancer or is suspicious for cancer * Both non-small cell lung cancer (including carcinoid tumors) and metastatic disease * The lesions should be: =\< 3 cm, located in the outer 2/3 of the lung, and leave \>= 1 cm of tumor-free lung parenchyma between target tumor and pleura or fissure Exclusion Criteria: * Tumors greater than 3 cm, located in the inner 1/3 of the lung, invading a major vessel, or located \< 1 cm from the pleural or fissure * Tumors qualified as non-resectable * Tumors that cannot be reached bronchoscopically * Patients declared non-surgical candidates * Patients who are not candidates for bronchoscopy * Patients with lung cancer who are found to have N2-3 disease * Patient with lung metastases who are found to have any malignant mediastinal lymph node * Patients in which the target lesion is confirmed as benign or small cell lung cancer * Patients without a prior diagnosis of the target lesion whose diagnosis cannot be made during bronchoscopy * Patients who have received chemotherapy within 60 days prior to bronchoscopic laser ablation * Patients who were previously treated for the target lesion * Pregnant patients
Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.
U.S. locations
- M D Anderson Cancer CenterHouston, Texas
Source and freshness
Processed from ClinicalTrials.gov. Last public update: Feb 16, 2023. Always confirm current availability with the study team.