TerminatedPhase 1NCT03674827

Vaccine-Based Immunotherapy Regimen For NSCLC and TNBC

Part 1of the study will evaluate the safety, pharmacokinetics, pharmacodynamics and immunogenicity of increasing doses of a vaccine-based immunotherapy regimen (VBIR-2) for patients with advanced or metastatic non-small cell lung cancer and metastatic triple-negative breast cancer. Part 2 will evaluate the safety, pharmacokinetics and pharmacodynamics, immunogenicity and preliminary evidence of efficacy of the Expansion dose of VBIR-2 in participants with advanced or metastatic non-small cell lung cancer.

Checked against the public recordLast updated Aug 23, 2024 · Source: ClinicalTrials.gov

StatusTerminated
PhasePhase 1
U.S. locations34
SponsorPfizer
01
Study overview

What this study is about

Purpose
Treatment
Study type
Interventional
Phase
Phase 1
Sponsor
Pfizer
Interventions being studied
Biological: PF-06936308
02
Explore related studies

How this study is categorized

These labels come from structured fields and exact terms in the public record.

03
Public criteria

Who may be able to participate

Inclusion Criteria: Part 1:Histological or cytological diagnosis of non-small cell lung cancer or triple-negative breast cancer. Adequate bone marrow, renal and liver function. Part 2: Histological or cytological diagnosis of metastatic non-small cell lung cancer previously treated with 1 or 2 regimens in metastatic setting including a CPI and platinum-based chemotherapy. Adequate bone marrow, renal and liver function. Exclusion Criteria: * Known symptomatic brain metastases * ECOG performance status greater than or equal to 2 * Concurrent immunotherapy * History of or active autoimmune disorders (including but not limited to: myasthenia gravis, thyroiditis, pneumonitis, rheumatoid arthritis, multiple sclerosis, systemic lupus, erythematosus, scleroderma) and other conditions that disorganize or alter the immune system. * History of inflammatory bowel disease. * Current use of any implanted electronic stimulation device, such as cardiac demand pacemakers, automatic implantable cardiac defibrillator, nerve stimulators, or deep brain stimulators. * Presence of any surgical or traumatic metal implants at the site of administration

Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.

04
Study sites

U.S. locations

  • UCSD Medical Center - EncinitasEncinitas, California
  • UC San Diego Medical Center - La Jolla (Jacobs Medical Center / Thornton Hospital)La Jolla, California
  • UC San Diego Perlman Medical OfficesLa Jolla, California
  • UC San Diego Moores Cancer CenterLa Jolla, California
  • Ronald Reagan UCLA Medical CenterLos Angeles, California
  • UCLA Hematology/OncologyLos Angeles, California
  • UC San Diego Medical Center - HillcrestSan Diego, California
  • UCLA Hematology/Oncology - ParksideSanta Monica, California
  • UCLA Hematology/Oncology - Santa MonicaSanta Monica, California
  • UCSD Medical Center - VistaVista, California
  • H Lee Moffitt Cancer Center & Research Institute IncTampa, Florida
  • The University of Chicago Medical Center, CCD - Investigational Drug Service PharmacyChicago, Illinois

Source and freshness
Processed from ClinicalTrials.gov. Last public update: Aug 23, 2024. Always confirm current availability with the study team.

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