Trial of Photodynamic Therapy Versus Argon Plasma Coagulation for Lung Cancer With Endobronchial Obstruction

Inclusion Criteria: * Written informed consent obtained from the subject and the ability for the subject to comply with all the study-related procedures. * Subjects must have a biopsy proven for non-small cell lung cancer with obstructing or partially obstructing endobronchial tumor involving the main stem bronchus or bronchus intermedius, or lobar bronchus with or without extrabronchial tumor. * Both males and females ≥ eighteen years of age * Subject must demonstrate at least a 50% airway stenosis due to endobronchial tumor. * Subject must demonstrate symptoms of cough, hemoptysis, dyspnea etc. attributable to partially or completely occluding endobronchial tumor. * Subject is able to tolerate multiple bronchoscopies. * Subjects who were previously treated with chemotherapy or radiotherapy are eligible for study entry. Such subjects must be at least 2 weeks post-radiotherapy and must have recovered from all acute toxicities associated with such treatment. * A predicted life expectancy of at least 90 days. Exclusion Criteria: * Prior treatment of non-small cell carcinoma with PDT or with APC in the last 3 months. * Subjects with tracheal lesions or carinal lesions that compromise both main stem bronchi. * Subjects who have undergone pneumonectomy. * Tumor involving or eroding into major blood vessels. * Presence of a tracheoesophageal or bronchoesophageal fistula. * Subjects receiving concurrent external beam radiation therapy. * Radiation therapy within the previous two weeks. * Inability to adhere to sunlight precautions. * Severe hepatic impairment. * Severe renal impairment. * Porphyria or hypersensitivity to porphyrins. * Subjects requiring supplemental O2 with a flow of greater than 3 lpm to keep resting oxygen saturations greater than 90%. * History of any other disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of protocol therapy or that might affect the interpretation of the results of the study or that puts the subject at high risk for treatment complications, in the opinion of the treating physician. * Prisoners or subjects who are involuntarily incarcerated. * Subjects who are compulsorily detained for treatment of either a psychiatric or physical illness. * Subjects demonstrating an inability to comply with the study and/or follow-up procedures. * Females who are pregnant. * Individuals who cannot provide consent themselves.