MP0250 DARPin® Protein Plus Osimertinib in Patients With EGFR-mutated NSCLC

1. Histologically confirmed metastatic or unresectable locally advanced non-squamous NSCLC with documented EGFR mutation-positive disease 2. Radiologically documented disease progression on previous osimertinib treatment. 3. Radiologically documented disease progression on or after most recent antitumor therapy. 4. Measurable disease according to RECIST 1.1. 5. Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0 2. 6. Men and women ≥18 years old on the day of signing informed consent. 7. Adequate hematological, hepatic and renal function prior to first dose 8. Serum albumin concentration ≥30 g/L 9. Potassium and magnesium within normal range

1. Necrotic tumors or tumors close to large blood vessels that may impose an increased bleeding risk when treated with anti-VEGF agents. 2. Second malignancy that is currently clinically significant or required active intervention during the period of 12 months prior to Screening, except early stage non-melanoma skin cancer treated with curative intent. 3. Known pre-existing interstitial or inflammatory lung disease. 4. Clinical signs of or documented leptomeningeal carcinomatosis. Features such as headache, nuchal rigidity, and photophobia may indicate meningeal involvement. 5. Known brain metastases who are clinically unstable 6. Prohibited anti-NSCLC therapies and not having recovered from related AEs to Common Terminology Criteria for Adverse Events (CTCAE) Grade ≤1 7. Any investigational drug within 28 days prior to study treatment. 8. Current participation in any other interventional clinical study (except survival follow up). 9. Neuropathy as residual toxicity after prior antitumor therapy Grade \>2 10. Patients taking medications that have the potential to prolong the QT interval 11. Significant cardiac abnormalities 12. Uncontrolled hypertension 13. Significant risk for bleeding 14. Active or recent thrombolic events