PDR001 Plus LAG525 for Patients With Advanced Solid and Hematologic Malignancies
The purpose of this signal seeking study is to determine whether treatment with PDR001 and LAG525 demonstrates sufficient efficacy in advanced malignancies to warrant further study.
Checked against the public recordLast updated May 27, 2022 · Source: ClinicalTrials.gov
What this study is about
- Purpose
- Treatment
- Study type
- Interventional
- Phase
- Phase 2
- Sponsor
- Novartis Pharmaceuticals
- Interventions being studied
- Biological: PDR001; Biological: LAG525
How this study is categorized
These labels come from structured fields and exact terms in the public record.
Who may be able to participate
Inclusion Criteria: Patients eligible for inclusion in this study had to meet all of the following criteria: * Patient must have had at least one prior line of therapy for their disease and must not be beyond 4th progression/relapse of disease (5 maximum prior lines). * Patient has a pathology confirmed diagnosis of a solid tumor or lymphoma listed in the section "condition". Patients must have measurable disease as per appropriate guidelines (Solid Tumors by RECIST 1.1 and Diffuse Large B-cell Lymphoma by Revised Response Criteria for Malignant Lymphoma - Cheson et al 2007). Exclusion Criteria: Patients eligible for this study must not meet any of the following criteria: * History of severe hypersensitivity reactions to other monoclonal antibodies. * Impaired cardiac function or clinically significant cardiac disease. * Active, known or suspected autoimmune disease or a documented history of autoimmune disease within three years prior to screening with a few exceptions as per protocol. * Patients previously exposed to anti-PD-1/PD-L1 treatment who are adequately treated for skin rash or with replacement therapy for endocrinopathies should not be excluded. * Patient with second primary malignancy within \< 3 years of first dose of study treatment. * Prior immunotherapy treatment with PD-1, PD-L1, CTLA-4, or LAG-3 antibodies.
Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.
U.S. locations
- California Pacific Medical Center Drug Shipment (2)San Francisco, California
- Hematology Oncology Associates of the Treasure CoastPort Saint Lucie, Florida
- University Cancer and Blood Center, LLCAthens, Georgia
- Northwestern University Medical SchoolChicago, Illinois
- University of Illinois Cancer Center at Chicago SCChicago, Illinois
- Illinois Cancer Care P.C. Jesse Brown VAPeoria, Illinois
- Indiana UniversityIndianapolis, Indiana
- University of Iowa Hospitals and Clinics Comprehensive Cancer CenterIowa City, Iowa
- The University of Kansas Clinical Research CenterFairway, Kansas
- Weinberg Cancer Institute at Franklin Square HospitalBaltimore, Maryland
- Billings Clinic Dept of Billings Clinic(2)Billings, Montana
- Oncology Hematology West Nebraska Cancer SpecialistsOmaha, Nebraska
Source and freshness
Processed from ClinicalTrials.gov. Last public update: May 27, 2022. Always confirm current availability with the study team.