Early Intrapleural TPA Instillation Versus Late
Chest tubes are used for air or fluid removal from the pleural space. When a chest tube is placed, it can be hard for the fluid to drain.Tissue plasminogen activator (tPA) and DNase are given through the chest tube to help with draining the fluid. We are doing this research to see if early addition of tPA-DNase immediately after chest tube placement will help with better fluid draining.
Checked against the public recordLast updated Feb 21, 2025 · Source: ClinicalTrials.gov
What this study is about
- Purpose
- Treatment
- Study type
- Interventional
- Phase
- Phase 4
- Sponsor
- Prisma Health-Midlands
- Interventions being studied
- Combination Product: early tPA and DNase
How this study is categorized
These labels come from structured fields and exact terms in the public record.
Who may be able to participate
Inclusion Criteria: * Adult patients, age 18 years or older * Patients with an indication for a thoracostomy tube placement for a pleural effusion Exclusion Criteria: * Patients that require a thoracostomy tube for a pneumothorax * Pregnant women * Sensitivity to t-PA, or DNase * Patients taking carbamazepine or nitroglycerin * Lung volume reduction surgery on side of pleural effusion
Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.
U.S. locations
- Palmetto Health RichlandColumbia, South Carolina
Source and freshness
Processed from ClinicalTrials.gov. Last public update: Feb 21, 2025. Always confirm current availability with the study team.