Functional Imaging in Lung SBRT
Little is known about the safety of body radiation therapy (SBRT), especially the impact on pulmonary function, quality of life, and on functional changes within the lung itself. Radiation dose constraints and capturing functional changes on imaging are not well studied in this setting. The current study aims to evaluate the utility of advanced imaging to measure lung function prior to and after treatment and to assess the feasibility of using this data to adapt SBRT planning.
Checked against the public recordLast updated Oct 17, 2019 · Source: ClinicalTrials.gov
What this study is about
- Purpose
- Not specified
- Study type
- Observational
- Phase
- Not applicable
- Sponsor
- University of Michigan Rogel Cancer Center
- Interventions being studied
- Other: CT Scan; Other: Lung CT; Other: MRI; Other: Walk Test; Other: SGRQ; Other: Biological Sample Collection; Other: Toxicity; Other: Cardiac Assessment
How this study is categorized
These labels come from structured fields and exact terms in the public record.
Who may be able to participate
Inclusion Criteria: * Patients receiving SBRT lung treatment and who have any one of the following high risk features: * Lung lesion \> 5 cm * DLCO \< 35% * FEV1 \< 0.5 L * Central lung tumors (defined as within 2 cm from the proximal bronchial tree) * Tumors that abut the great vessels, trachea, spinal cord, or esophagus * Prior lobectomy or pneumonectomy * Prior lung radiation (SBRT or conventional definitive lung radiation) * Patients must be 18 years of age or older Exclusion Criteria: * Patients who have received targeted agents or systemic potentially radiosensitizing chemotherapy within 2 weeks of lung SBRT start * Pregnancy or lactation * Unable to tolerate MRI without anesthesia * Inability cooperate with the scans
Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.
U.S. locations
- University of MichiganAnn Arbor, Michigan
Source and freshness
Processed from ClinicalTrials.gov. Last public update: Oct 17, 2019. Always confirm current availability with the study team.