Two Radiation Dose Schedules of SBRT to Lung Metastases < 5cm in Dimension
30 Gy single fraction of SBRT for lung metastases will result in comparable oncologic outcomes to 18Gy in three fractions (or dosing to a BED \</-100Gy at the discretion of the radiation oncologist) with respect to disease control and toxicity.
Checked against the public recordLast updated Oct 15, 2018 · Source: ClinicalTrials.gov
What this study is about
- Purpose
- Treatment
- Study type
- Interventional
- Phase
- Phase 2
- Sponsor
- Ronald McGarry
- Interventions being studied
- Radiation: Stereotactic Body Radiation Therapy
How this study is categorized
These labels come from structured fields and exact terms in the public record.
Who may be able to participate
Inclusion Criteria: * Histological confirmation of malignant carcinoma/sarcoma (any site) with metastasis to lung. * Patients must not be eligible for therapy with curative intent (i.e. surgery, radiation, etc). * Patients must have measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension * Age ≥18 years * ECOG performance status \>/= 2 (Karnofsky≥60%)). * Ability to understand and the willingness to sign a written informed consent document. Exclusion Criteria: * Patients with more than \>/=3 metastatic lung lesions or any one lesion greater than 5 cm. and/or extensive metastatic disease outside the chest. * Patients who are receiving any other investigational agents. * Patients with active systemic, pulmonary, or pericardial infection. * Pregnant or lactating women * Patients with known brain metastases should be excluded from this clinical trial because of their poor prognosis and because they often develop progressive neurologic dysfunction that would confound the evaluation of neurologic and other adverse events. * Uncontrolled inter-current illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements. * Chemotherapy concurrent with SBRT is not allowed
Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.
U.S. locations
- University of KentuckyLexington, Kentucky
Source and freshness
Processed from ClinicalTrials.gov. Last public update: Oct 15, 2018. Always confirm current availability with the study team.