Exercise Effect on Chemotherapy-Induced Neuropathic Pain
Chemotherapy-induced peripheral neuropathy (CIPN) continues to be a serious healthcare concern. It is painful, persistent, resistant to conventional pain therapies, and results in long-term suffering and decreased quality of life for many cancer survivors. The role of exercise to decrease CIPN-related neuropathic pain (CIPN-NP) will be investigated, with the goal of identifying the mechanisms associated with this therapeutic approach to manage CIPN-NP.
Checked against the public recordLast updated Aug 6, 2024 · Source: ClinicalTrials.gov
What this study is about
- Purpose
- Treatment
- Study type
- Interventional
- Phase
- Not applicable
- Sponsor
- Baltimore VA Medical Center
- Interventions being studied
- Behavioral: aerobic exercise intervention; Other: control group; Behavioral: resistive training
How this study is categorized
These labels come from structured fields and exact terms in the public record.
Who may be able to participate
Inclusion Criteria: * Diagnosis with cancer, stage I-IV * History of treatment with oxaliplatin, docetaxel, or paclitaxel, either alone or in combination with other agents * Completion of chemotherapy \> 6 months \< 1 year * Ability to walk on a treadmill * Medical clearance from oncologist or primary care provider * Presence of CIPN per National Cancer Institute Common Toxicity Criteria grade 1-3 (0-no signs/symptoms, 1-minor loss of function, 2-increased symptoms not interfering with activities of daily living (ADLs), 3-severe symptoms interfering with ADL, 4-disabling, and 5 is death) * Score on Neuropathic Pain Scale \>1 * Age 21-70 Exclusion Criteria: * Denial of CIPN * Other motor/sensory neuropathy caused by other than chemotherapy (i.e.alcohol-related, autoimmune diseases, diabetes) * Coronary artery disease * History of \>1 chemotherapy regimen * Musculoskeletal conditions which preclude participation in an exercise training program * Pregnancy * Regular exerciser, defined as \>90 minutes per week of aerobic exercise and any resistive training
Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.
U.S. locations
- Baltimore VA Medical CenterBaltimore, Maryland
Source and freshness
Processed from ClinicalTrials.gov. Last public update: Aug 6, 2024. Always confirm current availability with the study team.