hTERT Immunotherapy Alone or in Combination With IL-12 DNA Followed by Electroporation in Adults With Solid Tumors at High Risk of Relapse
This is a Phase I, open label study to evaluate the safety, tolerability, and immunogenicity of INO-1400 or INO-1401 alone or in combination with INO-9012, delivered by electroporation in subjects with high-risk solid tumor cancer with no evidence of disease after surgery and standard therapy. Subjects will be enrolled into one of ten treatment arms. Subjects will be assessed according to standard of care. Restaging and imaging studies will be performed to assess disease relapse per NCCN guidelines. RECIST will be used to validate the findings in cases of relapse.
Checked against the public recordLast updated Nov 19, 2018 · Source: ClinicalTrials.gov
What this study is about
- Purpose
- Prevention
- Study type
- Interventional
- Phase
- Phase 1
- Sponsor
- Inovio Pharmaceuticals
- Interventions being studied
- Biological: INO-1400; Biological: INO-9012; Biological: INO-1401
How this study is categorized
These labels come from structured fields and exact terms in the public record.
Who may be able to participate
Inclusion Criteria: * 1\. Signed and dated written IRB approved informed consent; * 2\. Males or females aged ≥18 years; * 3\. Subjects with breast, lung or pancreatic carcinoma who are at high risk of relapse post definitive therapy at least 4 and no more than 24 weeks from completion of definitive therapy at the time of signing informed consent as described below for each indication: * Breast carcinoma: * Lung carcinoma: * Pancreatic carcinoma: * Head and neck squamous cell carcinoma: * Ovarian cancer: * Colorectal cancer * Gastric and esophageal cancer * Hepatocellular carcinoma Exclusion Criteria: * 1\. Previous treatment wth any TERT or IL-12 containing therapy, or any other DNA immunotherapy; * 2\. Any concurrent condition requiring the continued or anticipated use of systemic steroids (excluding non-systemic inhaled, topical skin and/or eye drop-containing corticosteroids) or immunosuppressive therapy (excludes low dose methotrexate). All other systemic corticosteroids must be discontinued at least 4 weeks prior to first Study Treatment; * 3\. Administration of any vaccine within 4 weeks of the first study treatment
Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.
U.S. locations
- Barbara Ann Karmanos Cancer InstituteDetroit, Michigan
- Mayo ClinicRochester, Minnesota
- University of North CarolinaChapel Hill, North Carolina
- University of PennsylvaniaPhiladelphia, Pennsylvania
- Thomas Jefferson University HospitalPhiladelphia, Pennsylvania
- University of PittsburghPittsburgh, Pennsylvania
Source and freshness
Processed from ClinicalTrials.gov. Last public update: Nov 19, 2018. Always confirm current availability with the study team.