Concordance of Inivata Liquid Biopsy With Standard of Care Tissue Testing

Inclusion Criteria: * Written, signed and dated informed consent to participate in the study must be given by the patient in accordance with 21 CFR Part 312, the International Conference on Harmonisation (ICH) Good Clinical Practice (GCP) Guideline E6, and applicable regulations, before completing any study-related procedures. * Male and female patients aged 18 years and over diagnosed with stage IIIb/IV non-squamous NSCLC. * Arms A and B: Patients intended to initiate first-line treatment according to standard guidelines. Note, a patient is eligible to receive sterotactic radiosurgery (no whole-brain radiotherapy). Arm C: Patients who are at a second-line treatment setting or greater may participate. Note, a patient may be included if they have metastatic brain lesions. Arms A, B, C: If enrolled in a treatment clinical trial, patients may also enroll in this study if all eligibility criteria are met. * Arm A only: Patients intended to initiate first-line treatment according to standard guidelines who plan to have or have had a recent tumor tissue biopsy taken for molecular profiling as part of their standard of care. * Patient must understand and be able, willing and likely to fully comply with all study procedures and restrictions. Exclusion Criteria: * Patients who have received any approved or experimental cancer therapy since their most recent NSCLC tissue biopsy (Arms A and B) * Patients who have any other prior metastatic or current second primary cancer (Arms A and B) * Patient who has a severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or may interfere with the interpretation of study results and, in the judgment of the Investigator, would make the patient inappropriate for entry into this study.