Improving Pulmonary Function Following Radiation Therapy

Study summary

The purpose of this study is to develop radiation plans that will help preserve lung function in healthy tissue surrounding the tumor. We believe that 4DCT scans can be useful in designing radiation treatment plans that help us avoid healthy normal functioning lung tissue close to lung tumors. Currently 4DCT scans are used to help us determine exactly where the tumor is and how it moves when you breathe. In this study we will also use the 4DCT scans to try to identify high functioning normal lung tissue.

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Key things to know

Main goalTreatment

This describes the study’s primary purpose.

What is being studiedLaboratory Biomarker Analysis and Standard fractionation

Plus 2 other study approaches.

Who it may be forNon-small cell lung cancer (NSCLC)

These are broad labels—not an eligibility decision.

Checked against the public recordLast updated Jul 6, 2026 · Source: ClinicalTrials.gov

Is enrollment open?Completed

Ask the study team to confirm whether enrollment is open.

What kind of study?Not applicable

Interventional

Where is it offered?2 U.S. locations

Locations may change over time.

Who runs it?University of Wisconsin, Madison

Study sponsor

Study overview

What this study is about

Purpose: Treatment
Study type: Interventional
Phase: Not applicable
Sponsor: University of Wisconsin, Madison
Interventions being studied: Other: Laboratory Biomarker Analysis; Radiation: Standard fractionation; Radiation: Stereotactic Body Radiation Therapy (SBRT); Procedure: Four Dimensional Computed Tomographic Imaging (4DCT)

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How this study is categorized

These labels come from structured fields and exact terms in the public record.

Cancer type

Non-small cell lung cancer (NSCLC)→

Treatment approach

Radiation therapy→

Public criteria

Who may be able to participate

The sponsor separates these requirements into two groups. You do not need to interpret them alone—use them to guide a conversation with the study team.

Requirements people may need to meetInclusion criteria

Histologic diagnosis of non-small cell lung cancer or lung metastasis from a solid tumor. One biopsy site is adequate for multiple sites of thoracic disease.
Treatment includes localized radiation therapy with or without chemotherapy
Karnofsky ≥ 60%
Not pregnant per radiation oncology standard procedures
Ability to understand and the willingness to sign a written informed consent document

Reasons someone may not be able to joinExclusion criteria

Prior (within last 6 months) or future planned therapeutic surgery for the treatment of the existing lung cancer
Prior thoracic radiotherapy
Severe COPD defined as disease requiring an inpatient stay for respiratory deterioration within the past 3 months
Oxygen dependence of \> 2 L/min continuously throughout the day at baseline
Known underlying collagen vascular disease or intrinsic lung disease that could complicate expected sequelae of radiation (idiopathic pulmonary fibrosis, Wegener's granulomatosis)
Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.

Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.

Study sites

U.S. locations

UW Johnson CreekJohnson Creek, Wisconsin
University of Wisconsin Carbone Cancer CenterMadison, Wisconsin

Source and freshness
Processed from ClinicalTrials.gov. Last public update: Jul 6, 2026. Always confirm current availability with the study team.

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