CompletedPhase 1 / Phase 2NCT02658890

An Investigational Immuno-therapy Study of BMS-986205 Given in Combination With Nivolumab and in Combination With Both Nivolumab and Ipilimumab in Cancers That Are Advanced or Have Spread

The purpose of the study is to determine safety and effectiveness of experimental medication BMS-986205 when combined with Nivolumab and in combination with both Nivolumab and Ipilimumab in patients with cancers that are advanced or have spread. Pharmacokinetics and pharmacodynamics of BMS-986205 when combined with Nivolumab and in combination with Nivolumab and Ipilimumab in this patient population will also be assessed.

Checked against the public recordLast updated Aug 28, 2023 · Source: ClinicalTrials.gov

StatusCompleted
PhasePhase 1 / Phase 2
U.S. locations47
SponsorBristol-Myers Squibb
01
Study overview

What this study is about

Purpose
Treatment
Study type
Interventional
Phase
Phase 1 / Phase 2
Sponsor
Bristol-Myers Squibb
Interventions being studied
Drug: BMS-986205; Drug: Nivolumab; Drug: Ipilimumab
02
Explore related studies

How this study is categorized

These labels come from structured fields and exact terms in the public record.

03
Public criteria

Who may be able to participate

For more information regarding Bristol-Myers Squibb (BMS) Clinical Trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: * During dose escalation, subjects with advanced solid tumors that have progressed following at least one standard regimen * During cohort expansion, subjects with advanced cancer that either have received at least one prior therapy or are treatment naive, depending on the specified tumor type * Subjects must have measurable disease * Subject must consent to provide previously collected tumor tissue and a tumor biopsy during screening. * At least 4 weeks since any previous treatment for cancer * Must be able to swallow pills or capsules * Eastern Cooperative Oncology Group(ECOG) Performance Status 0-1 Exclusion Criteria: * Active or chronic autoimmune diseases * Uncontrolled or significant cardiovascular disease * History of any chronic Hepatitis, active Hepatitis B or C, human immunodeficiency virus (HIV), or acquired immune deficiency syndrome (AIDS) * Chronic hepatitis: Positive test for Hepatitis B virus surface antigen or Hepatitis C antibody (except for subjects with hepatocellular carcinoma) * Active central nervous system (CNS) metastases and CNS metastases as the only sites of disease * Active infection Other protocol defined inclusion/exclusion criteria could apply

Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.

04
Study sites

U.S. locations

  • Local Institution - 0028Tucson, Arizona
  • Local Institution - 0026La Jolla, California
  • Local Institution - 0035Tampa, Florida
  • Local Institution - 0005Atlanta, Georgia
  • Local Institution - 0048Atlanta, Georgia
  • Local Institution - 0027Chicago, Illinois
  • Local Institution - 0051Lutherville, Maryland
  • Local Institution - 0049Detroit, Michigan
  • Local Institution - 0006St Louis, Missouri
  • Local Institution - 0033Hackensack, New Jersey
  • Local Institution - 0041New York, New York
  • Local Institution - 0030Cleveland, Ohio

Source and freshness
Processed from ClinicalTrials.gov. Last public update: Aug 28, 2023. Always confirm current availability with the study team.

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