Concurrent Chemotherapy Plus HFR Radiation Therapy in Inoperable NSCLC

Inclusion Criteria: * Pathologically or cytologically proven diagnosis of non-small cell lung carcinoma. * Solitary \[T1bN0M0, T2aN0M0, T2bN0M0\] lesion measuring 2-7cm in size. Staging is per AJCC 7th edition of TNM classification. * Patient must meet criteria for receipt of hypofractionated radiation therapy * Medically inoperable pulmonary status, cardiac status, or other serious co-morbidity, or patient refusal of primary surgery for lung cancer. * ECOG Performance status of 0-2. * Patients may have prior treatment for lung cancer based on the following criteria: 1. Surgical resection is allowed if surgery was \> 12 months ago. 2. Patients treated with prior radiation are eligible if radiation was \> 12 months ago and there is no evidence of progression and if the lesion is in a different lobe. 3. Prior chemotherapy if \> 18 months ago Exclusion Criteria: * Node positive or metastatic disease. * Other active malignancy (specifically, risk of recurrence in 3 years estimated to be greater than 50%) except for non-melanoma skin cancer, in-situ cervical carcinoma (CIN), or low-risk prostate carcinoma on active surveillance are to be excluded. * Inability to receive systemic therapy or radiation therapy per protocol. * Inability to fulfill requirements of the protocol. * Any co-morbidity or condition which, in the opinion of the investigator, may interfere with the assessments and procedures of this protocol.