Diffusion-weighted MRI for Individualized Radiation Therapy Planning of Lung Cancer

Study summary

This clinical trial studies diffusion-weighted magnetic resonance imaging (MRI) in identifying and localizing tumors in patients with non-small cell lung cancer undergoing radiation therapy. Diagnostic procedures such as diffusion weighted MRI may help identify where active cancer is to improve the targeting accuracy of radiotherapy. Comparing results of diagnostic procedures done before, during, and after radiation therapy may help determine how the location and volume of tumors changes over time and predict how the tumor will respond to therapy.

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Key things to know

Main goalDiagnostic

This describes the study’s primary purpose.

What is being studieddiffusion-weighted magnetic resonance imaging and 4-dimensional computed tomography

Plus 2 other study approaches.

Who it may be forNon-small cell lung cancer (NSCLC) · Recurrent or relapsed

These are broad labels—not an eligibility decision.

Checked against the public recordLast updated Dec 16, 2016 · Source: ClinicalTrials.gov

Is enrollment open?Withdrawn

Ask the study team to confirm whether enrollment is open.

What kind of study?Not applicable

Interventional

Where is it offered?1 U.S. location

Locations may change over time.

Who runs it?Virginia Commonwealth University

Study sponsor

Study overview

What this study is about

Purpose: Diagnostic
Study type: Interventional
Phase: Not applicable
Sponsor: Virginia Commonwealth University
Interventions being studied: Device: diffusion-weighted magnetic resonance imaging; Device: 4-dimensional computed tomography; Radiation: fludeoxyglucose F 18; Device: FDG-PET

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How this study is categorized

These labels come from structured fields and exact terms in the public record.

Cancer type

Non-small cell lung cancer (NSCLC)→

Disease setting

Recurrent or relapsed→

Treatment approach

Radiation therapy→

Public criteria

Who may be able to participate

The sponsor separates these requirements into two groups. You do not need to interpret them alone—use them to guide a conversation with the study team.

Requirements people may need to meetInclusion criteria

Patients must be able to undergo MRI imaging; contrast application will be determined according to institutional guidelines; patients with lung cancer or locally recurrent lung cancer (following surgery) who are scheduled to receive external beam radiation therapy for at least 6 weeks
Tumor visible on planning CT scan
Negative pregnancy test for women of childbearing potential prior to study entry

Reasons someone may not be able to joinExclusion criteria

Patients requiring continuous supplemental oxygen
Patients with metal implants including pace makers and defibrillators
Patients with cerebral aneurysm clips or middle ear implant
Patients with pain pump, a programmable shunt, or non-surgical metal (i.e. a foreign body)
Claustrophobic patients
Prior radiotherapy to body area under investigation
No vulnerable populations will be enrolled (prisoners, children, pregnant females, or institutionalized individuals)

Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.

Study sites

U.S. locations

Virginia Commonwealth University Massey Cancer CenterRichmond, Virginia

Source and freshness
Processed from ClinicalTrials.gov. Last public update: Dec 16, 2016. Always confirm current availability with the study team.

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