SPECT/CT in Measuring Lung Function in Patients With Cancer Undergoing Radiation Therapy

Inclusion Criteria: * Cancer patients receiving radiation treatment to the thorax to at least 45 Gy; patient must have pathologic confirmation of diagnosis, or have an enlarging lung mass on at least two scans spaced 3 months apart, and FDG avidity on PET scan * Patients must be planned for at least 45 Gy of thoracic radiation * Patients are not required to have measurable disease; post-operative patients (patients who have had surgical resection of the lung) are eligible * Patients must have pulmonary function as defined below: * Abnormal pulmonary function test within 3 months of study entry * Prior radiation to the lungs * Prior surgical resection of lung tissue (i.e. wedge resection, lobectomy, or pneumonectomy) * Clinical diagnosis of chronic obstructive pulmonary disease (COPD) or emphysema * Ongoing oxygen use * There are no limits on prior therapy; patients are allowed to have prior chemotherapy, radiation therapy, and surgery; patients are allowed to have concurrent chemotherapy with radiation treatment; patients are allowed to have chemotherapy after radiation treatment; patients are not allowed to have planned lung resection after radiation * Ability to understand and the willingness to sign a written informed consent document * Patients will typically be enrolled on this trial prior to beginning the radiation treatment course; however, if a patient has had a SPECT/CT 99mTc-MAA and 99mTc-DTPA scan as part of routine medical care within 6 weeks prior to initiation of radiation treatment, he/she is eligible for trial enrollment up to the last day of the radiation treatment course Exclusion Criteria: * Patients must not be planned for lung resection after radiation therapy * Patients receiving \< 45 Gy radiation * Patients who received radiation to the chest within the past 6 months * Patients unable to tolerate a SPECT/CT 99mTc-MAA and 99mTc-DTPA scan * Patients who are not planning to adhere to the required follow up schedule as outlined in this protocol * Pregnant women * Women of childbearing potential and men who are sexually active and not willing/able to use medically acceptable forms of contraception * Patients unable to provide informed consent