trūFreeze® Spray Cryotherapy Patient Registry

Inclusion Criteria: 1. GI conditions include: * Barrett's Esophagus (BE) with or without dysplasia * Squamous dysplasia * Esophageal cancer, any stage 2. Pulmonary conditions include: * Any endobronchial cancerous or precancerous disease located within the central airways * Any non-malignant endobronchial process of the central airways that results in abnormal mucosa (i.e. granulation tissue, papillomatosis, sarcoidosis, tuberculosis, etc.) * Tracheal or bronchial stenosis (malignant or benign) * Any pleural disease, malignant or benign All subjects are required to be able to provide written informed consent Exclusion Criteria: 1. Gastrointestinal Exclusion Criteria * Contraindication to spray cryotherapy. * Prior treatment with spray cryotherapy. Previous or concurrent treatment using other mucosal therapies such as endoscopic mucosal resection or radiofrequency ablation is acceptable. * Below 18 years of age 2. Pulmonary Exclusion Criteria * Contraindication to spray cryotherapy. * Prior treatment with spray cryotherapy. Previous or concurrent treatment using other mucosal therapies is acceptable. * Tracheoesophageal fistula. * Bronchopleural fistula. * Current untreated pneumothorax. * Clinically significant hypoxia refractory to supplemental oxygen therapy. * Below 18 years of age