A Study of Alectinib (RO5424802) in Participants With Non-Small Cell Lung Cancer Who Have Anaplastic Lymphoma Kinase (ALK) Mutation and Failed Crizotinib Treatment
This open-label, non-randomized, multicenter, Phase 1/2 study will evaluate the safety and efficacy of alectinib in participants with non-small cell lung cancer who have ALK mutation and failed crizotinib treatment. In Part 1, cohorts of participants will receive escalating doses of alectinib orally twice daily. In Part 2, participants will receive the recommended phase 2 dose (RP2D) of alectinib as determined in Part 1. Treatment will continue in Part 1 and Part 2 on the same dose until disease progression. In Part 3, following disease progression, participants without epidermal growth factor receptor (EGFR) mutation will be offered continued treatment with alectinib, participants with EGFR mutations will be offered a combination of alectinib and erlotinib.
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Checked against the public recordLast updated Nov 2, 2018 · Source: ClinicalTrials.gov
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Interventional
Locations may change over time.
Study sponsor
What this study is about
- Purpose
- Treatment
- Study type
- Interventional
- Phase
- Phase 1 / Phase 2
- Sponsor
- Hoffmann-La Roche
- Interventions being studied
- Drug: Erlotinib; Drug: Alectinib
How this study is categorized
These labels come from structured fields and exact terms in the public record.
Who may be able to participate
The sponsor separates these requirements into two groups. You do not need to interpret them alone—use them to guide a conversation with the study team.
- Locally advanced or metastatic non-small cell lung cancer (stage IIIB or IV by American Joint Committee on Cancer \[AJCC\])
- Eastern Cooperative Oncology Group (ECOG) performance status 0-2
- Documented ALK rearrangement based on Food and Drug Administration (FDA)-approved test
- Prior treatment with crizotinib and progression according to response evaluation criteria in solid tumors version 1.1 (RECIST v1.1) criteria. Participants had to have a minimum 1-week wash-out period between the last dose of crizotinib and the first dose of study treatment. Participants can either be chemotherapy-naïve or have received at least one line of platinum-based chemotherapy
- Adequate hematologic, hepatic, and renal function
- Participants with brain or leptomeningeal metastases are allowed if protocol defined criteria are met
- Measurable disease according to RECIST v1.1 prior to administration of first dose of study drug
- Receipt of any other ALK inhibitors in addition to crizotinib
- Receipt of any prior cytotoxic chemotherapy for ALK-positive NSCLC within 4 weeks prior to the first dose of study drug
- Participants who received crizotinib or any other tyrosine kinase inhibitors need to have a minimum 1-week washout period before the first dose of study drug
- Active or uncontrolled infectious diseases requiring treatment
- National Cancer Institute Common Terminology Criteria for Adverse Events version 4.03 (NCI CTCAE v4.03) Grade 3 or higher toxicities due to prior therapy that have not shown improvement and are considered to interfere with current study medication
- History of organ transplant
- Co-administration of anti-cancer therapies other than those administered in this study
- Baseline corrected Q-T interval (QTc) greater than (\>) 470 milliseconds, or baseline symptomatic bradycardia (less than 45 heart beats per minute)
- Pregnant or breastfeeding women
- Known Human Immunodeficiency Virus (HIV) positivity or Acquired Immunodeficiency Syndrome (AIDS)-related illness
- History of hypersensitivity to any of the additives in the alectinib formulation
- Any clinically significant concomitant disease or condition that could interfere with, or for which treatment might interfere with, the conduct of the study, or absorption of oral medications, or that would, in the opinion of the principal investigator, pose an unacceptable risk to the participant in the study
Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.
U.S. locations
- University of Alabama at BirminghamBirmingham, Alabama
- St. Jude Heritage HealthcareFullerton, California
- UC Irvine Medical CenterOrange, California
- Sharp Memorial HospitalSan Diego, California
- Coastal Integrative Cancer CareSan Luis Obispo, California
- UCLA Cancer Center; Premiere Oncology, A Medical CorporationSanta Monica, California
- Advanced Medical SpecialtiesMiami, Florida
- Florida Hospital Cancer InstOrlando, Florida
- Rush University Medical CenterChicago, Illinois
- Midwestern Regional Medical Center; Office of ResearchZion, Illinois
- Washington University; Wash Uni. Sch. Of MedSt Louis, Missouri
- Comprehensive Cancer Centers of NevadaHenderson, Nevada
Source and freshness
Processed from ClinicalTrials.gov. Last public update: Nov 2, 2018. Always confirm current availability with the study team.