Chest Imaging, Breath, and Biomarkers in a Screening Trial

Study summary

The investigators would like to see if lung cancer screening with chest x-rays,computer aided detection (CAD)and a lose dose CT scan can detect lung cancer in early stages when it is more responsive to treatment. The investigators would also like to see if early detection will reduce the incidence of symptomatic advanced lung cancer compared to no screening in former and current smokers with or without a family history of lung cancer who are 40-75 years old.

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Key things to know

Main goalNot specified

This describes the study’s primary purpose.

What is being studiedchest x-ray with or without CAD, lose dose CT scan

The study team can explain what participation involves.

Who it may be forEarly-stage or resectable

These are broad labels—not an eligibility decision.

Checked against the public recordLast updated May 18, 2017 · Source: ClinicalTrials.gov

Is enrollment open?Completed

Ask the study team to confirm whether enrollment is open.

What kind of study?Not applicable

Observational

Where is it offered?1 U.S. location

Locations may change over time.

Who runs it?The Cleveland Clinic

Study sponsor

Study overview

What this study is about

Purpose: Not specified
Study type: Observational
Phase: Not applicable
Sponsor: The Cleveland Clinic
Interventions being studied: Device: chest x-ray with or without CAD, lose dose CT scan

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How this study is categorized

These labels come from structured fields and exact terms in the public record.

Disease setting

Early-stage or resectable→

Public criteria

Who may be able to participate

The sponsor separates these requirements into two groups. You do not need to interpret them alone—use them to guide a conversation with the study team.

Requirements people may need to meetInclusion criteria

ages 40-75 years
If ages 40-59, then one of the following criteria needs to be met:
Current or ex-smoker with \>25 pack years and a family history of lung cancer(parent or sibling) OR
current or ex-smoker with \> 25 pack years and COPD OR
current or ex-smoker with a \> 35 pack year history
If ages 60-75, then one of the following additional criteria needs to be met:
Current or ex-smoker with \>25 pack years and a family history of lung cancer (parent or sibling) OR
Current or ex-smoker with \>25 pack years and COPD OR
Current or ex-smoker with a \>30 pack year history
Subject is able to return to Cleveland Clinic for annual follow-up screening
Subject is willing to sign a medical release form

Reasons someone may not be able to joinExclusion criteria

Current health requires oxygen
Have had a chest x-ray or CT of the chest within the last 6 months
Previous pneumonectomy
Lobectomy of the lung within the last 5 years
Diagnosed malignancy within the last 5 years, excluding non-melanoma skin cancer, carcinoma in situ of the cervix and localized prostate cancer
A medical condition that would prevent treatment for lung cancer
Within the last 6 weeks, one of the following has occured:
A new cough or chronic cough that has gotten worse
Either new shortness of breath, or any worsening of shortness of breath
A cough producing blood
Constant chest pain
Respiratory infection, pneumonia, or cold
Unintentional and unexplained weight loss greater than 5% of total body weight

Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.

Study sites

U.S. locations

Cleveland ClinicCleveland, Ohio

Source and freshness
Processed from ClinicalTrials.gov. Last public update: May 18, 2017. Always confirm current availability with the study team.

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