Stereotactic Body Radiation for Consolidation After Standard Chemoradiation for Stage 3 Lung Cancer

PATIENT ELIGIBILITY Conditions for Patient Eligibility (Inclusion) * Pathologically or cytologically confirmed NSCLC * Stage III NSCLC according to the AJCC 7th edition staging criteria. Stage II (T1-3N1) patient that are deemed medically inoperable are also eligible. * Concurrent chemoradiation to a radiation dose of 50.4 Gy. * residual tumor volume after concurrent chemoradiation that is appropriate for SBRT: * Primary tumor \<120cc (approximately 6cm diameter). * Mediastinal/Hilar disease: 1-2 involved regions \<60cc (approximately 5cmx3cmx3cm) * Absolute neutrophil count ≥ 1,000/uL, platelet ≥ 60,000/uL. * Total bilirubin ≤ 2x upper institutional limit of normal (ULN), and AST or ALT ≤5x ULN. * ECOG performance status 0 to 2 * Minimum life expectancy of 12 weeks. * Age older than 18 years. * Voluntary, signed written informed consent. * Women of childbearing potential must have a negative pregnancy test * Men and women of childbearing potential must be willing to consent to using effective contraception while on treatment and for at least 1 months thereafter. Conditions for Patient Ineligibility (Exclusion) * Disease progression during or after standard chemoradiation to 50.4 Gy * Prior thoracic radiation other than the pre-operative radiation not greater than 50.4 * Metastatic disease * Uncontrolled severe, intercurrent illness. * Women who are breast-feeding. * No chemotherapy within 2 weeks from the first SBRT treatment. * Concurrent anticancer therapy. * Prior complete resection of all NSCLC.