Collecting and Studying Tissue Samples From Patients With HIV-Associated Malignancies
RATIONALE: Collecting and studying tissue samples from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research trial studies collecting tissue samples from patients with HIV-related malignancies.
Checked against the public recordLast updated Mar 16, 2023 · Source: ClinicalTrials.gov
What this study is about
- Purpose
- Not specified
- Study type
- Observational
- Phase
- Not applicable
- Sponsor
- AIDS Malignancy Consortium
- Interventions being studied
- Genetic: DNA analysis; Genetic: RNA analysis; Genetic: gene expression analysis; Genetic: polymorphism analysis; Other: biologic sample preservation procedure; Other: flow cytometry; Other: medical chart review
How this study is categorized
These labels come from structured fields and exact terms in the public record.
Who may be able to participate
DISEASE CHARACTERISTICS: * Participants must have a diagnosis of a malignancy or clinical findings suggestive of a possible HIV-associated malignancy of one of three types: * Diffuse large B-cell lymphoma * Non-small cell lung malignancy * The presence of any of the following conditions will exclude a participant from study enrollment: * Absence of sufficient diagnostic tumor-biopsy tissue material to meet the protocol requirements for baseline specimen submission (minimum specimen size of 10 x 10 x 2 mm); repeat tumor biopsy will not be performed solely to meet the protocol specimen-collection requirements * Participants whose biopsies, for the purpose of this protocol, show a diagnosis of anal intraepithelial neoplasia or cervical intraepithelial neoplasia * Prior treatment for the study malignancy (including neo-adjuvants), since treatment can affect the mutational spectra of tumors * HIV infection based on serologic documentation of HIV infection at any time prior to study entry, as evidenced by positive enzyme-linked immunosorbent assay (ELISA), positive western blot, or any other Food and Drug Administration (FDA)-approved (licensed) HIV test; alternatively, this documentation may include a record that another physician has documented that the patient has HIV based on prior ELISA and western blot, or other approved diagnostic tests PATIENT CHARACTERISTICS: * Participants must be willing and able to sign an IRB-approved informed consent document PRIOR CONCURRENT THERAPY: * See Disease Characteristics
Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.
U.S. locations
- Moores UCSD Cancer CenterLa Jolla, California
- UCLA Clinical AIDS Research and Education (CARE) CenterLos Angeles, California
- George Washington UniversityWashington D.C., District of Columbia
- University of MiamiMiami, Florida
- John H. Stroger Hospital of Cook CountyChicago, Illinois
- Louisiana State University Public HospitalNew Orleans, Louisiana
- Washington University School of MedicineSt Louis, Missouri
- Memorial Sloan Kettering Cancer CenterNew York, New York
- Albert Einstein Cancer Center at Albert Einstein College of MedicineThe Bronx, New York
- UNC Lineberger Comprehensive Cancer CenterChapel Hill, North Carolina
- University of Pennsylvania - Abramson Cancer Center at Pennsylvania HospitalPhiladelphia, Pennsylvania
- Fox Chase Cancer CenterPhiladelphia, Pennsylvania
Source and freshness
Processed from ClinicalTrials.gov. Last public update: Mar 16, 2023. Always confirm current availability with the study team.