TerminatedNot applicableNCT01567722

Collecting and Studying Tissue Samples From Patients With HIV-Associated Malignancies

RATIONALE: Collecting and studying tissue samples from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research trial studies collecting tissue samples from patients with HIV-related malignancies.

Checked against the public recordLast updated Mar 16, 2023 · Source: ClinicalTrials.gov

StatusTerminated
PhaseNot applicable
U.S. locations14
SponsorAIDS Malignancy Consortium
01
Study overview

What this study is about

Purpose
Not specified
Study type
Observational
Phase
Not applicable
Sponsor
AIDS Malignancy Consortium
Interventions being studied
Genetic: DNA analysis; Genetic: RNA analysis; Genetic: gene expression analysis; Genetic: polymorphism analysis; Other: biologic sample preservation procedure; Other: flow cytometry; Other: medical chart review
02
Explore related studies

How this study is categorized

These labels come from structured fields and exact terms in the public record.

03
Public criteria

Who may be able to participate

DISEASE CHARACTERISTICS: * Participants must have a diagnosis of a malignancy or clinical findings suggestive of a possible HIV-associated malignancy of one of three types: * Diffuse large B-cell lymphoma * Non-small cell lung malignancy * The presence of any of the following conditions will exclude a participant from study enrollment: * Absence of sufficient diagnostic tumor-biopsy tissue material to meet the protocol requirements for baseline specimen submission (minimum specimen size of 10 x 10 x 2 mm); repeat tumor biopsy will not be performed solely to meet the protocol specimen-collection requirements * Participants whose biopsies, for the purpose of this protocol, show a diagnosis of anal intraepithelial neoplasia or cervical intraepithelial neoplasia * Prior treatment for the study malignancy (including neo-adjuvants), since treatment can affect the mutational spectra of tumors * HIV infection based on serologic documentation of HIV infection at any time prior to study entry, as evidenced by positive enzyme-linked immunosorbent assay (ELISA), positive western blot, or any other Food and Drug Administration (FDA)-approved (licensed) HIV test; alternatively, this documentation may include a record that another physician has documented that the patient has HIV based on prior ELISA and western blot, or other approved diagnostic tests PATIENT CHARACTERISTICS: * Participants must be willing and able to sign an IRB-approved informed consent document PRIOR CONCURRENT THERAPY: * See Disease Characteristics

Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.

04
Study sites

U.S. locations

  • Moores UCSD Cancer CenterLa Jolla, California
  • UCLA Clinical AIDS Research and Education (CARE) CenterLos Angeles, California
  • George Washington UniversityWashington D.C., District of Columbia
  • University of MiamiMiami, Florida
  • John H. Stroger Hospital of Cook CountyChicago, Illinois
  • Louisiana State University Public HospitalNew Orleans, Louisiana
  • Washington University School of MedicineSt Louis, Missouri
  • Memorial Sloan Kettering Cancer CenterNew York, New York
  • Albert Einstein Cancer Center at Albert Einstein College of MedicineThe Bronx, New York
  • UNC Lineberger Comprehensive Cancer CenterChapel Hill, North Carolina
  • University of Pennsylvania - Abramson Cancer Center at Pennsylvania HospitalPhiladelphia, Pennsylvania
  • Fox Chase Cancer CenterPhiladelphia, Pennsylvania

Source and freshness
Processed from ClinicalTrials.gov. Last public update: Mar 16, 2023. Always confirm current availability with the study team.

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