S1013: Validation of Cancer Questionnaire for Skin Toxicities in Patients With Colorectal Cancer or Lung Cancer Receiving Cetuximab, Panitumumab, or Erlotinib Hydrochloride
RATIONALE: Questionnaires that patients can use to assess skin toxicities related to treatment may help identify the intermediate-and long-term effects of cetuximab, panitumumab, or erlotinib hydrochloride. PURPOSE: This trial studies the validation of a cancer questionnaire for skin toxicities in patients with colorectal or lung cancer receiving cetuximab, panitumumab, or erlotinib hydrochloride.
Checked against the public recordLast updated Dec 15, 2022 · Source: ClinicalTrials.gov
What this study is about
- Purpose
- Not specified
- Study type
- Observational
- Phase
- Not applicable
- Sponsor
- SWOG Cancer Research Network
- Interventions being studied
- Procedure: assessment of therapy complications; Procedure: psychosocial assessment and care; Procedure: quality-of-life assessment
How this study is categorized
These labels come from structured fields and exact terms in the public record.
Who may be able to participate
DISEASE CHARACTERISTICS: * Patients must have a diagnosis of colorectal or lung cancer and be planning to receive one of the following epidermal growth factor receptor (HER1/EGFR) inhibitor therapies listed below for at least 6 weeks: * Cetuximab 400 mg/m² loading dose, 250 mg/m² weekly * Cetuximab 500 mg/m² every 2 weeks * Panitumumab 6 mg/kg every 2 weeks * Erlotinib hydrochloride 100-150 mg daily * Other HER1/EGFR inhibitor therapies, schedules, or doses of the above listed agents are not allowed * Concurrent chemotherapy and other anti-cancer therapies (such as carboplatin, paclitaxel, and bevacizumab) are allowed EXCEPT for the following chemotherapeutic agents that are known to cause skin rash that could interfere with EGFRI-induced skin toxicity assessment: gemcitabine, capecitabine, and topical fluorouracil (Efudex™, Fluoroplex™, Carac™) * Patients must have completed the baseline S1013 Functional Assessment of Cancer Therapy- (FACT) EGFRI 18 within 7 days prior to registration PATIENT CHARACTERISTICS: * Patients must have a Zubrod performance status of 0-2 * Patients must not have any of the following serious concomitant skin disorders that, in the investigator's opinion, could interfere with assessment of epidermal growth factor receptor inhibitor (EGFRI)-induced skin toxicity: atopic dermatitis \[eczema\]; contact dermatitis; psoriasis; rosacea; severe photosensitivity; scleroderma; steroid-induced acne; or xerosis * Patients must be able to complete questionnaires in English PRIOR CONCURRENT THERAPY: * See Disease Characteristics * Patients may have had prior epidermal growth factor receptor (HER1/EGFR) inhibitor therapy but must have fully recovered from any skin toxicities prior to registration * Patients must not be planning to receive any of the following concomitant medications that can cause skin rash or other dermatologic reactions that could interfere with the EGFRI-induced skin toxicity assessments, for the duration of the study: allopurinol; systemic corticosteroids; topical retinoids (Retin-A™, Tretinoin™); or oral retinoids (Amnesteem™, Claravis™, Sotret™) * Patients must not be planning to receive concurrent external-beam radiation therapy, including prophylactic cranial radiation * Patients may concurrently participate in other therapeutic clinical trials
Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.
U.S. locations
- University of Arizona Cancer Center-North CampusTucson, Arizona
- The University of Arizona Medical Center-University CampusTucson, Arizona
- East Bay Radiation Oncology CenterCastro Valley, California
- City of Hope Comprehensive Cancer CenterDuarte, California
- Epic Care-DublinDublin, California
- Bay Area Breast Surgeons IncEmeryville, California
- Epic Care Partners in Cancer CareEmeryville, California
- UC San Diego Moores Cancer CenterLa Jolla, California
- Loma Linda University Medical CenterLoma Linda, California
- Los Angeles County-USC Medical CenterLos Angeles, California
- USC / Norris Comprehensive Cancer CenterLos Angeles, California
- Contra Costa Regional Medical CenterMartinez, California
Source and freshness
Processed from ClinicalTrials.gov. Last public update: Dec 15, 2022. Always confirm current availability with the study team.