Bavituximab Plus Carbo and Pemetrexed in Chemo-Naive Stage IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC) Subjects

Inclusion Criteria: * Greater than or equal to 18 * Histologically or cytologically confirmed stage IV non-squamous NSCLC not previously treated with systemic chemotherapy * Evaluable disease by clinical or radiographic parameters * No history or concomitant malignancy * Adequate organ and marrow function * Female subjects with negative urine or serum pregnancy * ECOG must be 0 or 1 Exclusion Criteria: * Squamous cell, small cell, or mixed histology * Known history of bleeding diathesis or coagulopathy * Cavitary tumors or tumors invading or abutting large blood vessels * Any history of thromboembolic events * Ongoing therapy with oral or parenteral anticoagulants * Major surgery within 4 weeks of Day 1 of treatment * Uncontrolled intercurrent disease (diabetes, hypertension, thyroid disease) * any history of significant vascular disease * Congestive heart failure * History of any condition requiring anti-platelet therapy * Serious non healing wound * Known chronic infection with human immunodeficiency virus (HIV) or viral hepatitis * Unable or unwilling to discontinue use of prohibited medications * D-dimers \>2 x ULN as measured on 2 separate occasions at least 1 day apart