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CompletedNot applicableNCT01158456
Official study title

Metabolism of NNK Among African Americans

Study summary

Metabolism and DNA adduct formation are critical in cancer induction by NNK. The investigators goal is to understand whether the observed ethnic/racial differences in lung cancer incidence are due to variations in NNK metabolism. The investigators overall hypothesis is that cancer susceptibility relates to carcinogen dose and to the balance between carcinogen metabolic activation and detoxification. The investigators propose to test this hypothesis via investigation of potential differences in NNK metabolic activation and detoxification in African American and European American smokers.

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Key things to know

Main goalNot specified

This describes the study’s primary purpose.

What is being studiedNot specified

The study team can explain what participation involves.

Who it may be forLung Cancer

These are broad labels—not an eligibility decision.

Checked against the public recordLast updated Apr 10, 2023 · Source: ClinicalTrials.gov

Is enrollment open?Completed

Ask the study team to confirm whether enrollment is open.

What kind of study?Not applicable

Observational

Where is it offered?1 U.S. location

Locations may change over time.

Who runs it?Masonic Cancer Center, University of Minnesota

Study sponsor

01
Study overview

What this study is about

Purpose
Not specified
Study type
Observational
Phase
Not applicable
Sponsor
Masonic Cancer Center, University of Minnesota
Interventions being studied
Not specified
02
Explore related studies

How this study is categorized

These labels come from structured fields and exact terms in the public record.

03
Public criteria

Who may be able to participate

The sponsor separates these requirements into two groups. You do not need to interpret them alone—use them to guide a conversation with the study team.

Requirements people may need to meetInclusion criteria
  • 1. Male or female subjects with a smoking history of at least 10 cigarettes daily for at least 1 year; 2. Subjects report themselves, biological parents and both sets of biological grandparents as
  • African American or African descent or
  • European American or European descent 3. Subjects are in apparently good physical health (no unstable medical condition) 4. Subjects are in stable, good mental health (e.g. not currently, within the past 6 months, experiencing unstable or untreated psychiatric diagnosis, including substance abuse, as determined by the PRIME-MD); 5. Subjects have provided written informed consent to participate in the study.
Reasons someone may not be able to joinExclusion criteria

1. Unstable medical conditions including cancer, coronary heart disease and arrhythmia 2. Cannot or unwilling to identify ethnic/racial ancestry 3. Women who are currently pregnant or breast feeding 4. Currently using any other tobacco or nicotine-containing product 5. Currently taking any medications that affect relevant metabolic enzymes.

Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.

04
Study sites

U.S. locations

  • Tobacco Research Programs University of MinnesotaMinneapolis, Minnesota

Source and freshness
Processed from ClinicalTrials.gov. Last public update: Apr 10, 2023. Always confirm current availability with the study team.

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