Metabolism of NNK Among African Americans
Metabolism and DNA adduct formation are critical in cancer induction by NNK. The investigators goal is to understand whether the observed ethnic/racial differences in lung cancer incidence are due to variations in NNK metabolism. The investigators overall hypothesis is that cancer susceptibility relates to carcinogen dose and to the balance between carcinogen metabolic activation and detoxification. The investigators propose to test this hypothesis via investigation of potential differences in NNK metabolic activation and detoxification in African American and European American smokers.
Checked against the public recordLast updated Apr 10, 2023 · Source: ClinicalTrials.gov
What this study is about
- Purpose
- Not specified
- Study type
- Observational
- Phase
- Not applicable
- Sponsor
- Masonic Cancer Center, University of Minnesota
- Interventions being studied
- Not specified
How this study is categorized
These labels come from structured fields and exact terms in the public record.
Who may be able to participate
Inclusion Criteria: 1. Male or female subjects with a smoking history of at least 10 cigarettes daily for at least 1 year; 2. Subjects report themselves, biological parents and both sets of biological grandparents as * African American or African descent or * European American or European descent 3. Subjects are in apparently good physical health (no unstable medical condition) 4. Subjects are in stable, good mental health (e.g. not currently, within the past 6 months, experiencing unstable or untreated psychiatric diagnosis, including substance abuse, as determined by the PRIME-MD); 5. Subjects have provided written informed consent to participate in the study. Exclusion Criteria: 1. Unstable medical conditions including cancer, coronary heart disease and arrhythmia 2. Cannot or unwilling to identify ethnic/racial ancestry 3. Women who are currently pregnant or breast feeding 4. Currently using any other tobacco or nicotine-containing product 5. Currently taking any medications that affect relevant metabolic enzymes.
Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.
U.S. locations
- Tobacco Research Programs University of MinnesotaMinneapolis, Minnesota
Source and freshness
Processed from ClinicalTrials.gov. Last public update: Apr 10, 2023. Always confirm current availability with the study team.