Stereotactic Body Radiotherapy and Radiofrequency Ablation for Lung Tumors Near Central Airways
The purpose of this study is to demonstrate that combined stereotactic body radiotherapy and radiofrequency ablation is safe for patients with lung tumors near central airways.
Checked against the public recordLast updated May 6, 2019 · Source: ClinicalTrials.gov
What this study is about
- Purpose
- Treatment
- Study type
- Interventional
- Phase
- Not applicable
- Sponsor
- Jonsson Comprehensive Cancer Center
- Interventions being studied
- Radiation: Stereotactic Body Radiation; Radiation: Radiofrequency Ablation
How this study is categorized
These labels come from structured fields and exact terms in the public record.
Who may be able to participate
Inclusion Criteria: * Histologically confirmed primary lung cancer, lung metastasis from another primary, or recurrent tumors in the setting of prior RFA or cryotherapy * Tumors \< 2 cm from trachea or zone of proximal bronchial tree (central tumors) * Each tumor \< 5 cm in size prior to treatment * Medically inoperable patients as determined at the multidisciplinary thoracic tumor board, or medically operable patients who refuse surgery * Criterion for medical inoperability include: * Overall clinical assessment at the UCLA thoracic tumor board * Reduced Pulmonary Function (FEV1, DLCO, etc) based on one major or two minor criterion as described below: * Modified ACOSOG Criteria for medical inoperability: * Major Criteria: FEV1% \< 50% or \< 1L and DLCO \< 50% * Minor Criteria: Age \> 75, FEV1 51-60% predicted, or FEV1 1-1.2L, DLCO 51%-60% predicted, pulmonary hypertension, poor left ventricular function (EF \< 40% or less), resting or exercise arterial pO2 \< 55 mmHg, and pCO2 \> 45 mmHg * Age \> 18 years old * KPS \> 70 * If a woman is of childbearing potential, a negative urine or serum pregnancy test must be documented. * Ability to understand and the willingness to sign a written informed consent Exclusion Criteria: * Prior thoracic radiation near the targets of interest * More than 2 central tumor targets per patient * Active infections requiring systemic antibiotics
Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.
U.S. locations
- UCLA Jonsson Comprehensive Cancer CenterLos Angeles, California
Source and freshness
Processed from ClinicalTrials.gov. Last public update: May 6, 2019. Always confirm current availability with the study team.