CompletedNot applicableNCT01051037

Stereotactic Body Radiotherapy and Radiofrequency Ablation for Lung Tumors Near Central Airways

The purpose of this study is to demonstrate that combined stereotactic body radiotherapy and radiofrequency ablation is safe for patients with lung tumors near central airways.

Checked against the public recordLast updated May 6, 2019 · Source: ClinicalTrials.gov

StatusCompleted
PhaseNot applicable
U.S. locations1
SponsorJonsson Comprehensive Cancer Center
01
Study overview

What this study is about

Purpose
Treatment
Study type
Interventional
Phase
Not applicable
Sponsor
Jonsson Comprehensive Cancer Center
Interventions being studied
Radiation: Stereotactic Body Radiation; Radiation: Radiofrequency Ablation
02
Explore related studies

How this study is categorized

These labels come from structured fields and exact terms in the public record.

Treatment approach
03
Public criteria

Who may be able to participate

Inclusion Criteria: * Histologically confirmed primary lung cancer, lung metastasis from another primary, or recurrent tumors in the setting of prior RFA or cryotherapy * Tumors \< 2 cm from trachea or zone of proximal bronchial tree (central tumors) * Each tumor \< 5 cm in size prior to treatment * Medically inoperable patients as determined at the multidisciplinary thoracic tumor board, or medically operable patients who refuse surgery * Criterion for medical inoperability include: * Overall clinical assessment at the UCLA thoracic tumor board * Reduced Pulmonary Function (FEV1, DLCO, etc) based on one major or two minor criterion as described below: * Modified ACOSOG Criteria for medical inoperability: * Major Criteria: FEV1% \< 50% or \< 1L and DLCO \< 50% * Minor Criteria: Age \> 75, FEV1 51-60% predicted, or FEV1 1-1.2L, DLCO 51%-60% predicted, pulmonary hypertension, poor left ventricular function (EF \< 40% or less), resting or exercise arterial pO2 \< 55 mmHg, and pCO2 \> 45 mmHg * Age \> 18 years old * KPS \> 70 * If a woman is of childbearing potential, a negative urine or serum pregnancy test must be documented. * Ability to understand and the willingness to sign a written informed consent Exclusion Criteria: * Prior thoracic radiation near the targets of interest * More than 2 central tumor targets per patient * Active infections requiring systemic antibiotics

Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.

04
Study sites

U.S. locations

  • UCLA Jonsson Comprehensive Cancer CenterLos Angeles, California

Source and freshness
Processed from ClinicalTrials.gov. Last public update: May 6, 2019. Always confirm current availability with the study team.

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