Hydroxychloroquine With or Without Erlotinib in Advanced Non-small Cell Lung Cancer (NSCLC)

Inclusion Criteria: * Pathologically confirmed diagnosis of non-small cell lung cancer * Stage IIIB with pleural effusion or Stage IV disease by the American Joint Committee on Cancer (AJCC) 6th edition staging criteria. * At least 12 weeks of prior treatment with erlotinib, gefitinib, or another EGFR small molecule TKI agent. * Age equal to or greater than 18 years * Measurable disease, defined according to RECIST criteria * Performance status of 0, 1 or 2 * At least 2 weeks since prior radiation treatment * At least 2 weeks since any prior chemotherapy or targeted therapy * Adequate organ function as outlined in the protocol * Approval for HCQ treatment by an eye doctor, based on a screening eye exam. Examples of disqualifying baseline conditions include macular degeneration and other retinal disease. * Willingness to comply with protocol procedures including the blood-sampling schedule for PK analyses and periodic eye examination Exclusion Criteria: * Current use of hydroxychloroquine for any reason * Known hypersensitivity to chloroquine, hydroxychloroquine, or any other closely related drug * Known hypersensitivity to erlotinib, gefitinib, or any closely related drug * Glucose-6-phosphate dehydrogenase (G6PD) deficiency, as HCQ may cause hemolytic anemia in patients with G6PD deficiency * Cataracts that would interfere with required funduscopic examinations, or severe baseline visual impairment including macular degeneration, retinopathy or visual field changes, or having only one functional eye. All patients must undergo a screening eye exam prior to enrollment * Pregnancy or breastfeeding. Female subjects of childbearing age and male subjects must practice acceptable method of birth control * Symptomatic CNS metastases or newly diagnosed CNS metastases that have not yet been definitively treated with radiation and/or surgery * Prior radiation therapy inclusive of all identified target lesions * Any evidence of clinically active interstitial lung disease * Malignancies within the past 3 years except for adequately treated carcinoma of the cervix or basal or squamous cell carcinomas of the skin * Although not an absolute exclusion criteria, caution should be exercised in patients with a diagnosis of porphyria or non-light sensitive psoriasis, as HCQ can significantly exacerbate both of those conditions * Evidence of any other significant clinical disorder or laboratory finding that makes it undesirable for the patient to participate in the study * Use of any non-FDA approved or investigational agent within 2 weeks of enrolling onto the trial, or failure to recover from the side effects of any of these agents * Penicillamine use for Wilson's disease or any other indication, as concomitant use with HCQ can increase toxicity to penicillamine