CompletedPhase 1NCT00890617

Cryotherapy in Treating Patients With Primary Stage I Non-Small Cell Lung Cancer or Lung Metastasis

RATIONALE: Cryotherapy kills tumor cells by freezing them. Giving cryotherapy before surgery may kill more tumor cells. PURPOSE: This phase I trial is studying how well cryotherapy works in treating patients with primary stage I non-small cell lung cancer or lung metastasis.

Checked against the public recordLast updated Nov 1, 2022 · Source: ClinicalTrials.gov

StatusCompleted
PhasePhase 1
U.S. locations1
SponsorBarbara Ann Karmanos Cancer Institute
01
Study overview

What this study is about

Purpose
Treatment
Study type
Interventional
Phase
Phase 1
Sponsor
Barbara Ann Karmanos Cancer Institute
Interventions being studied
Procedure: Cryotherapy (PTC); Drug: Prednisone
02
Explore related studies

How this study is categorized

These labels come from structured fields and exact terms in the public record.

03
Public criteria

Who may be able to participate

DISEASE CHARACTERISTICS: * Histologically or cytologically confirmed (by percutaneous transthoracic needle biopsy or transbronchial biopsy) diagnosis of 1 the following: * Non-small cell lung carcinoma * Stage I disease * Primary disease * No primary lung metastatic disease, satellite lesions of the chest, mediastinal lymph nodes \> 1.5 cm, hepatic or adrenal masses by the PET scan or the CT scan * Metastatic cancer to the lung * Must have a definitive cancer diagnosis with the primary tumor under local control and no metastatic disease other than to the lung * Solitary or multiple (≤ 3) peripheral lung lesions * No chemotherapy since the new metastatic lesion appeared * Measurable disease, defined as 1 lesion unidimensionally measured ≤ 3.0 cm by conventional CT scan techniques * Must be registered with the Clinical Trials office at the Karmanos Cancer Center/Wayne State University * Must be a candidate for a thoracotomy * No evidence of cerebral disease or metastatic disease of the brain PATIENT CHARACTERISTICS: * Neutrophil count \> 1,500/mm\^3 * Platelet count \> 75,000/mm\^3 * PT and PTT normal * FEV\_1 \> 1.0 L/sec * Diffusing capacity ≥ 30% * Not pregnant or nursing * No other uncontrolled or concurrent illnesses including, but not limited to, any of the following conditions: * Active infection * Heart failure * Unstable angina * Cardiac dysrhythmia * Psychiatric illness or a social situation that would limit compliance with the study requirements PRIOR CONCURRENT THERAPY: * See Disease Characteristics * No prior radiation therapy or chemotherapy for these particular tumors * No concurrent aspirin or other platelet-inhibiting drugs (e.g., coumadin or heparin) * No other concurrent experimental studies

Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.

04
Study sites

U.S. locations

  • Barbara Ann Karmanos Cancer InstituteDetroit, Michigan

Source and freshness
Processed from ClinicalTrials.gov. Last public update: Nov 1, 2022. Always confirm current availability with the study team.

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