Cryotherapy in Treating Patients With Primary Stage I Non-Small Cell Lung Cancer or Lung Metastasis
RATIONALE: Cryotherapy kills tumor cells by freezing them. Giving cryotherapy before surgery may kill more tumor cells. PURPOSE: This phase I trial is studying how well cryotherapy works in treating patients with primary stage I non-small cell lung cancer or lung metastasis.
Checked against the public recordLast updated Nov 1, 2022 · Source: ClinicalTrials.gov
What this study is about
- Purpose
- Treatment
- Study type
- Interventional
- Phase
- Phase 1
- Sponsor
- Barbara Ann Karmanos Cancer Institute
- Interventions being studied
- Procedure: Cryotherapy (PTC); Drug: Prednisone
How this study is categorized
These labels come from structured fields and exact terms in the public record.
Who may be able to participate
DISEASE CHARACTERISTICS: * Histologically or cytologically confirmed (by percutaneous transthoracic needle biopsy or transbronchial biopsy) diagnosis of 1 the following: * Non-small cell lung carcinoma * Stage I disease * Primary disease * No primary lung metastatic disease, satellite lesions of the chest, mediastinal lymph nodes \> 1.5 cm, hepatic or adrenal masses by the PET scan or the CT scan * Metastatic cancer to the lung * Must have a definitive cancer diagnosis with the primary tumor under local control and no metastatic disease other than to the lung * Solitary or multiple (≤ 3) peripheral lung lesions * No chemotherapy since the new metastatic lesion appeared * Measurable disease, defined as 1 lesion unidimensionally measured ≤ 3.0 cm by conventional CT scan techniques * Must be registered with the Clinical Trials office at the Karmanos Cancer Center/Wayne State University * Must be a candidate for a thoracotomy * No evidence of cerebral disease or metastatic disease of the brain PATIENT CHARACTERISTICS: * Neutrophil count \> 1,500/mm\^3 * Platelet count \> 75,000/mm\^3 * PT and PTT normal * FEV\_1 \> 1.0 L/sec * Diffusing capacity ≥ 30% * Not pregnant or nursing * No other uncontrolled or concurrent illnesses including, but not limited to, any of the following conditions: * Active infection * Heart failure * Unstable angina * Cardiac dysrhythmia * Psychiatric illness or a social situation that would limit compliance with the study requirements PRIOR CONCURRENT THERAPY: * See Disease Characteristics * No prior radiation therapy or chemotherapy for these particular tumors * No concurrent aspirin or other platelet-inhibiting drugs (e.g., coumadin or heparin) * No other concurrent experimental studies
Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.
U.S. locations
- Barbara Ann Karmanos Cancer InstituteDetroit, Michigan
Source and freshness
Processed from ClinicalTrials.gov. Last public update: Nov 1, 2022. Always confirm current availability with the study team.