Ixabepilone and Carboplatin +/- Bevacizumab in Advanced Non-Small-Cell Lung Cancer

• 1. Histologically confirmed non-small-cell bronchogenic carcinoma (squamous carcinoma, adenocarcinoma, or large cell carcinoma). Cytologic specimens obtained by brushings, washings, or needle aspiration of the defined lesion are acceptable. Mixed tumors with small-cell anaplastic elements are not eligible. 2. Patients who have newly diagnosed unresectable stage III or IV disease are eligible. Patients with stage III disease should be ineligible for combined modality therapy 3. Patients must not have received any prior antineoplastic chemotherapy for metastatic lung cancer prior to study entry. 4. Patients who have had previous radiotherapy as definitive therapy for locally advanced non-small-cell are eligible as long as the recurrence is outside the original radiation port. Radiation therapy must have been completed greater than 4 weeks prior to registration. 5. Male or female patients \>=18 years of age. 6. Life expectancy of at least 3 months. 7. ECOG performance status of \<=1. 8. Measurable disease by RECIST criteria (see Section 7). 9. Laboratory values as follows:
• ANC \>=1500/mm3 (7 days prior to treatment);
• Hemoglobin \>=8 g/dL;
• Platelets \>=100,000 mm3 (7 days prior to treatment)
• Bilirubin \<=1 x ULN for institution
• AST/SGOT \<=2.5 x ULN or \<=5.0 x ULN in patients with liver metastases and
• ALT/SGPT \<=2.5 x ULN or \<=5.0 x ULN in patients with liver metastases
• Creatinine \<=2.0 mg/dL or
• Calculated (measured) GFR \>=40 mL/min
• PT/INR and PTT \<=1.5 x ULN 10. Peripheral neuropathy \<= grade 1.

1. A history of cardiac disease as defined by malignant hypertension, unstable angina, congestive heart failure of \> grade 2 per New York Heart Association (NYHA) criteria (see Appendix B), myocardial infarction within the previous 6 months, or symptomatic cardiac arrhythmias. 2. Metastatic brain or meningeal tumors. 3. Uncontrolled intercurrent illness. 4. Chemotherapy, investigational drug therapy, or major surgery ≤ 4 weeks prior to starting study drug, or patients who have not recovered from side effects of previous therapy. 5. Patient is \<=5 years free of another primary malignancy, except if the other primary malignancy is not currently clinically significant or requiring active intervention, or if the other primary malignancy is a basal cell skin cancer or a cervical carcinoma in situ.