CompletedPhase 1NCT00526461

Photodynamic Therapy Using HPPH in Treating Patients With Stage 0 Non-Small Cell Lung Cancer

RATIONALE: Photodynamic therapy uses a drug, such as HPPH, that is absorbed by tumor cells. The drug becomes active when it is exposed to a certain kind of light. When the drug is active, tumor cells are killed. PURPOSE: This phase I trial is studying the side effects and best dose of photodynamic therapy using HPPH in treating patients with stage 0 non-small cell lung cancer.

Checked against the public recordLast updated Aug 4, 2023 · Source: ClinicalTrials.gov

StatusCompleted
PhasePhase 1
U.S. locations1
SponsorRoswell Park Cancer Institute
01
Study overview

What this study is about

Purpose
Treatment
Study type
Interventional
Phase
Phase 1
Sponsor
Roswell Park Cancer Institute
Interventions being studied
Drug: HPPH
02
Explore related studies

How this study is categorized

These labels come from structured fields and exact terms in the public record.

03
Public criteria

Who may be able to participate

DISEASE CHARACTERISTICS: * Biopsy confirmed carcinoma in situ (CIS) or microinvasive bronchogenic non-small cell lung carcinoma * May have squamous cell carcinoma, adenocarcinoma, or large cell carcinoma histology * Stage 0 (CIS or microinvasive) disease, meeting all of the following criteria: * Lesion must be radiographically occult and not definable by conventional CT scan of the chest * Lesion may or may not be invisible on white light bronchoscopy, but is definable and photographable on laser-induced fluorescence emission (LIFE) bronchoscopy * Biopsy of the lesion must indicate no evidence of invasion beyond cartilage on histopathology, but may be invasive through the basement membrane (microinvasive carcinoma) * No evidence of major pulmonary vessel encasement on CT scan of the chest PATIENT CHARACTERISTICS: * Karnofsky performance status (PS) 50-100% OR ECOG PS 0-2 * Platelet count ≥ 100,000/mm\^3 * WBC ≥ 4,000/mm\^3 * Prothrombin time ≤ 1.5 times upper limit of normal (ULN) * Total bilirubin ≤ 3.0 mg/dL * Creatinine ≤ 3.0 mg/dL * Alkaline phosphatase (hepatic) or SGOT ≤ 3 times ULN * No porphyria or hypersensitivity to porphyrin or porphyrin-like compounds * No severe chronic obstructive pulmonary disease, that in the opinion of the investigator, would preclude multiple bronchoscopies or partial central airway obstruction from mucous/debris formation * Patients with underlying lung disease must be judged (by the principal investigator) able to withstand mucous or debris formation at the site of treatment * No contraindications for bronchoscopy * Not pregnant * Negative pregnancy test * Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: * More than 4 weeks since prior and no concurrent chemotherapy or radiotherapy * Prior therapy of any type (e.g., chemotherapy or radiotherapy) allowed for lung cancer

Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.

04
Study sites

U.S. locations

  • Roswell Park Cancer InstituteBuffalo, New York

Source and freshness
Processed from ClinicalTrials.gov. Last public update: Aug 4, 2023. Always confirm current availability with the study team.

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