Photodynamic Therapy Using HPPH in Treating Patients With Stage 0 Non-Small Cell Lung Cancer
RATIONALE: Photodynamic therapy uses a drug, such as HPPH, that is absorbed by tumor cells. The drug becomes active when it is exposed to a certain kind of light. When the drug is active, tumor cells are killed. PURPOSE: This phase I trial is studying the side effects and best dose of photodynamic therapy using HPPH in treating patients with stage 0 non-small cell lung cancer.
Checked against the public recordLast updated Aug 4, 2023 · Source: ClinicalTrials.gov
What this study is about
- Purpose
- Treatment
- Study type
- Interventional
- Phase
- Phase 1
- Sponsor
- Roswell Park Cancer Institute
- Interventions being studied
- Drug: HPPH
How this study is categorized
These labels come from structured fields and exact terms in the public record.
Who may be able to participate
DISEASE CHARACTERISTICS: * Biopsy confirmed carcinoma in situ (CIS) or microinvasive bronchogenic non-small cell lung carcinoma * May have squamous cell carcinoma, adenocarcinoma, or large cell carcinoma histology * Stage 0 (CIS or microinvasive) disease, meeting all of the following criteria: * Lesion must be radiographically occult and not definable by conventional CT scan of the chest * Lesion may or may not be invisible on white light bronchoscopy, but is definable and photographable on laser-induced fluorescence emission (LIFE) bronchoscopy * Biopsy of the lesion must indicate no evidence of invasion beyond cartilage on histopathology, but may be invasive through the basement membrane (microinvasive carcinoma) * No evidence of major pulmonary vessel encasement on CT scan of the chest PATIENT CHARACTERISTICS: * Karnofsky performance status (PS) 50-100% OR ECOG PS 0-2 * Platelet count ≥ 100,000/mm\^3 * WBC ≥ 4,000/mm\^3 * Prothrombin time ≤ 1.5 times upper limit of normal (ULN) * Total bilirubin ≤ 3.0 mg/dL * Creatinine ≤ 3.0 mg/dL * Alkaline phosphatase (hepatic) or SGOT ≤ 3 times ULN * No porphyria or hypersensitivity to porphyrin or porphyrin-like compounds * No severe chronic obstructive pulmonary disease, that in the opinion of the investigator, would preclude multiple bronchoscopies or partial central airway obstruction from mucous/debris formation * Patients with underlying lung disease must be judged (by the principal investigator) able to withstand mucous or debris formation at the site of treatment * No contraindications for bronchoscopy * Not pregnant * Negative pregnancy test * Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: * More than 4 weeks since prior and no concurrent chemotherapy or radiotherapy * Prior therapy of any type (e.g., chemotherapy or radiotherapy) allowed for lung cancer
Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.
U.S. locations
- Roswell Park Cancer InstituteBuffalo, New York
Source and freshness
Processed from ClinicalTrials.gov. Last public update: Aug 4, 2023. Always confirm current availability with the study team.