TerminatedNot applicableNCT00424138

FDG-PET/CT Scans in Patients With Stage IIIB or Stage IV NSCLC Undergoing Chemotherapy

RATIONALE: Diagnostic procedures, such as fludeoxyglucose F 18 (\^18FDG) positron emission tomography (PET)/CT scans, may help doctors predict a patient's response to treatment and help plan the best treatment. PURPOSE: This clinical trial is studying \^18FDG PET/CT scans to see how well they predict response in patients undergoing chemotherapy for stage IIIB or stage IV non-small cell lung cancer.

Checked against the public recordLast updated Oct 11, 2018 · Source: ClinicalTrials.gov

StatusTerminated
PhaseNot applicable
U.S. locations1
SponsorAmerican College of Radiology Imaging Network
01
Study overview

What this study is about

Purpose
Diagnostic
Study type
Interventional
Phase
Not applicable
Sponsor
American College of Radiology Imaging Network
Interventions being studied
Radiation: FDG
02
Explore related studies

How this study is categorized

These labels come from structured fields and exact terms in the public record.

03
Public criteria

Who may be able to participate

DISEASE CHARACTERISTICS: * Histologically or cytologically confirmed non-small cell lung cancer * Newly diagnosed stage IIIB (with malignant pleural effusion) or stage IV disease (Group I and II), or newly diagnosed stage IIIA, IIIB, or IV (Group III) determined by all of the following: * CT scan or MRI of the chest and upper abdomen (including liver and adrenal glands) within the past 4 weeks * History/physical examination within the past 6 weeks * CT scan or MRI of the brain within the past 4 weeks, if there is headache, mental/physical impairment, or other signs or symptoms suggesting brain metastases within the past 2 months * No small cell carcinoma * No pure bronchioloalveolar carcinoma * Patients with recurrent or metastatic disease are eligible provided they meet 1 of the following criteria: * Received surgery or radiotherapy for treatment of the primary tumor and locoregional disease ≥ 3 months prior to study entry AND have a measurable lesion in the chest * Received chemotherapy in the adjuvant setting or as part of combined modality therapy for locoregional disease ≥ 3 months prior to recurrent or metastatic disease diagnosis AND have a measurable lesion in the chest * Measurable disease, defined as at least 1 measurable primary tumor or other intrathoracic/supraclavicular lesion ≥ 2 cm * Scheduled to be treated with a platinum-based dual-agent chemotherapy regimen administered at 3-week intervals with or without bevacizumab or cetuximab (Group I and II) * Scheduled to be treated with standard chemotherapy in the current protocol, other standard chemotherapy, experimental chemotherapy, or other treatment including no treatment (Group III) * No symptomatic brain metastases (Groups I and II only) PATIENT CHARACTERISTICS: * ECOG performance status 0-2 (Groups I and II only) * Group III may include potential participants regardless of ECOG performance status score * Not pregnant or nursing * Negative pregnancy test * Fertile patients must use effective contraception * Able to tolerate positron emission tomography (PET)/CT scanning * No contraindication to chemotherapy and PET/CT scanning, as demonstrated by laboratory testing * No poorly controlled diabetes (i.e., fasting glucose level \> 150 mg/dL) despite attempts to improve glucose control by fasting duration and adjustment of medications * No prior malignancy other than basal cell or squamous cell carcinoma of the skin, carcinoma in situ, or other cancer from which the patient has been disease free for ≥ 3 years (Groups I and II) * Prior malignancy is not an exclusion factor for Group III * No clinical or radiographic signs of post-obstructive pneumonia PRIOR CONCURRENT THERAPY: * See Disease Characteristics * More than 3 months since prior thoracic radiotherapy, lung surgery, or chemotherapy * Prior chemotherapy in the adjuvant setting or as part of a combined modality regimen for locoregional disease that was given ≥ 3 months prior to diagnosis of recurrent or metastatic disease allowed * No planned treatment with any targeted biologic therapy including gefitinib or erlotinib hydrochloride (Group I and II) * No concurrent chemoradiotherapy * No concurrent bevacizumab

Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.

04
Study sites

U.S. locations

  • Jonsson Comprehensive Cancer Center at UCLALos Angeles, California

Source and freshness
Processed from ClinicalTrials.gov. Last public update: Oct 11, 2018. Always confirm current availability with the study team.

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